Ra-223联合戈舍瑞林治疗前列腺癌骨转移的疗效  

作　　者：包鹏飞 叶俊杰 徐昭宇 张会江[1] 

机构地区：[1]浙江省丽水市人民医院,323000

出　　处：《浙江临床医学》2018年第1期44-46,共3页Zhejiang Clinical Medical Journal

摘　　要：目的观察二氯化镭-223（Ra-223dichloride）联合戈舍瑞林治疗前列腺癌骨转移的疗效。方法采用前瞻性研究，将前列腺癌骨转移患者84例按数字表法随机纳入对照组（单用Ra-223）或观察组（Ra-223＋戈舍瑞林），每组各42例。比较两组患者治疗前后骨转移灶数、骨痛程度、生活质量、血清前列腺特异性抗原（PSA）、血清游离前列腺特异性抗原（f-PSA）、治疗效果及不良反应发生率的差异。结果治疗后，观察组骨转移灶数少于对照组，差异有统计学意义（u=l971，P=0．049）。治疗后观察组与对照组在骨痛评分[（3．2±1．4）vs（5．3±12）]、生活质量改善率（66．7％vs42．8％）、PSA[（8．9±3．7）vs（23．2±8．4）]、f-PSA[（4．5±1．2）vs（9．3±3．5）]、客观缓解率（52．4％vs33.3％），比较差异均有统计学意义（P〈0．05）。两组在药物不良反应发生率差异无统计学意义（P〉0．05）。结论Ra-223联合戈舍瑞林可缓解前列腺癌骨转移患者骨痛程度、减少骨转移灶、提升生活质量，并降低血清PSA、f-PSA含量，提高最终治疗效果。Objective To investigate the clinical evaluation of Ra-223 combined with goserelin in the treatment of bone metastases of prostate cancer. Methods A prospective study was conducted in 84 patients with prostate cancer who were randomized to the control group （ Ra-223 ） or observation group （Ra-223＋ goserelin ） , with 42 patients in each group. The differences of bone metastases, bone pain, quality of life, PSA, f-PSA, treatment effect and adverse reaction rate were compared between the two groups before and after treatment. Results After treatment, the number of bone metastases in the observation group was less than that in the control group, the difference was statistically significant （u=1.971, P=0.049 ） . At the same time, after treatment, the observation group and the control group had a bone pain score （ 3.2 ± 1.4 vs 5.3 ± 1.2 ） , quality of life improvement rate （ 56.7% vs 42.8% ） , PSA （ 8.9 ±3.7 vs 23.2 ± 8.4 ） , f-PSA （ 4.5 ± 1.2 vs 9.3 ± 3.5 ） , and the objective response rate （ 52.4% vs 33.3% ） , the difference was statistically significant （ P〈0.05 ） . In addition, there was no significant difference in the incidence of adverse drug reactions between the two groups （ P〉0.05 ） . Conclusion Ra-223 combined with goserelin can relieve the degree of bone pain in patients with bone metastasis of prostate cancer, reduce bone metastases, improve quality of life, and reduce serum PSA, f-PSA levels, improve the final treatment.

关 键 词：前列腺癌 骨转移 镭-223 戈舍瑞林 

分 类 号：R737.11[医药卫生—肿瘤]