趋化因子GRO-a在宫颈癌中的表达及意义  

作　　者：张隆英[1] 叶永志[1] 陈豪 

机构地区：[1]台州市中西医结合医院,浙江温岭317523 [2]杭州市第一人民医院,310002

出　　处：《浙江临床医学》2018年第1期55-56,共2页Zhejiang Clinical Medical Journal

摘　　要：目的探讨趋化因子生长相关癌基因（GRO—a）在宫颈癌中的作用。方法选取2012年1月至2016年1月宫颈癌患者23例（宫颈癌组），采用免疫组化方法检测GRo—a的表达。并与40例慢性宫颈炎患者（宫颈炎组）和40例宫颈上皮内瘤变患者（宫颈上皮内瘤变纽）比较。结果宫颈癌GRo—a蛋白的阳性率显著高于宫颈炎组和宫颈上皮内瘤变组，差异有统计学意义（x2=13．13，P〈O．05）；在宫颈癌组中，伴淋巴结转移组的GRo—a蛋白阳性率明显高于无淋巴结转移组，差异有统计学意义（x2=8．05，io〈0．05）。结论宫颈癌组织中GRO—a蛋白表达水平增加，故针对GRO—a的免疫治疗有一定的价值，值得进一步研究。Objective To evaluate the potential roles of growth-related oncogene alpha （ GRO-a ） in the pathogenesis of the cervical cancer. Methods Tissues from 23 patients with cervical cancer （ cervical cancer group ） who were from January 2012 to January 2016, 40 cases of chronic cervicitis （ cervicitis group ） and 40 cases of cervical intraepithelial neoplasia （ cervical intraepithelial neoplasia group ） were collected. Immunohistochemistry was used to detect the expression of GRO-a. Results The positive rate of GRO-a in cervical cancer group was significant higher than cervicitis group and cervical intraepithelial neoplasia group （ X 2=13-13, P〈0.05 ） ; and in cervical cancer group, the positive rate of GRO-a with lymph node metastasis group was significant higher than that of negative lymph node metastasis group （ X 2=8-05, P〈0.05 ） . Conclusion The expression levels of GRO-a in cervical cancer are increased, so the immunotherapy for GRO-a has a great potential and broad prospects and is worth further study.

关 键 词：宫颈肿瘤 免疫组织化学 生长相关癌基因 

分 类 号：R737.33[医药卫生—肿瘤]