中国儿童白血病发病与室内装修关系的Meta分析  

Relationship between indoor decoration and the incidence of childhood leukemia in China: a meta-analysis

作　　者：杨雯雯 孙业桓[1] 沈国栋[2] 程民[2] 徐婷娟[2] 胡世莲[2,3] 

机构地区：[1]安徽医科大学公共卫生学院流行病与卫生统计学系,合肥230032 [2]安徽省立医院肿瘤免疫与营养治疗安徽省重点实验室,合肥230001 [3]安徽省循证医学中心,合肥230001

出　　处：《中国循证医学杂志》2017年第12期1450-1455,共6页Chinese Journal of Evidence-based Medicine

基　　金：安徽省重点实验室绩效项目(编号:1606c08236)

摘　　要：目的系统评价室内装修对中国儿童白血病发病的影响。方法计算机检索CNKI、WanFang Data、VIP、CBM、PubMed、EMbase、The Cochrane Library数据库,搜集有关室内装修与中国儿童白血病发病相关的病例-对照研究,检索时限均从建库至2016年12月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入13个研究,包括病例组1 727例,对照组2 468例。Meta分析结果显示:与对照组相比,室内装修可增加中国儿童白血病的发病风险[OR=2.69,95%CI(1.82,3.98),P<0.000 01]。结论当前证据表明,室内装修是中国儿童白血病发病的危险因素。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objectives To systematically review the relationship between indoor decoration and childhood leukemia in China. Methods CNKI, WanFang Data, VIP, CBM, PubMed, EMbase and The Cochrane Library databases were electronically searched to obtain case-control studies of the relationships between indoor decoration and childhood leukemia from inception to December 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 13 studies involving 1 727 cases and 2 468 controls were included. The results of meta-analysis showed that indoor decoration could increase the risk of childhood leukemia in China （OR=2.69, 95%CI 1.82 to 3.98, P〈0.000 01）. Conclusions The current evidence suggests that indoor decoration is a risk factor for childhood leukemia in Chinese. Due to limited quality and quantity of the included studies, more high-quality studies are required to verify above conclusions.

关 键 词：儿童白血病 发病 危险因素 室内装修 系统评价 META分析 病例-对照研究 

分 类 号：R733.7[医药卫生—肿瘤]