扶正消瘤汤联合化疗治疗胃癌临床研究  

Clinical Study on Effect of Fuzheng Xiaoliu Tang Combined with Chemotherapy in Treating Gastric Cancer

作　　者：余俊奇[1] 刘尚岭[1] 

机构地区：[1]中国人民解放军第一五三中心医院,河南郑州450007

出　　处：《新中医》2017年第12期132-134,共3页New Chinese Medicine

基　　金：河南省中医药研究专项普通项目(2013ZY02026)

摘　　要：目的:观察扶正消瘤汤治疗胃癌患者的临床疗效,及其对肿瘤组织内血管生成抑制的影响。方法:将80例胃癌患者根据其标识的数字采用随机的方式分为2组各40例,对照组患者采用胃癌化疗方案FAM进行治疗,观察组在对照组治疗方案的基础上加用扶正消瘤汤进行治疗。比较观察2组患者的临床疗效及其对血管生成抑制的影响。结果:2组临床疗效比较,总有效率对照组70.0%,观察组92.5%,差异有统计学意义(P<0.05)。治疗后,观察组免疫功能指标Ig A、Ig G分别与对照组比较,差异均有统计学意义(P<0.05);2组患者血清血管内皮生长因子(VEGF)浓度较治疗前降低,差异均有统计学意义(P<0.05),观察组血清VEGF浓度与对照组比较,差异有统计学意义(P<0.05)。治疗后,观察组生存质量评分量表中自觉症状、躯体生理功能状态、日常生活、社会活动、总得分等评分分别与对照组比较,差异均有统计学意义(P<0.05)。结论:扶正消瘤汤治疗胃癌患者的疗效确切,对晚期胃癌患者VEGF有良好的抑制作用。Objective： To observe the clinical effect of Fuzheng Xiaoliu tang on gastric cancer patients and angiogenesis inhibition in tumor tissue. Methods： Selected 80 gastric cancer patients, and divided them into two groups according to random table method, 40 cases in each group. The control group received chemotherapy of FAM, while the observation group was given modified Fuzheng Xiaoliu tang based on the treatment of the controt group. Compared and observed clinical effect of two groups and effect of Fuzheng Xiaoliu tang on angiogenesis inhibition. Results.. Compared clinical effect of the two groups, the total effective rate was 70.0% in the control group and was 92.5% in the observation group, the difference being significant （P 〈0.05）. After treatment, compared IgA, IgG of the treatment group with those of the control group respectively, differences being significant（P〈0.05）. The concentration of serum vascular endothelial growth factor（VEGF）in both groups was lower than that before, the difference being significant （P 〈 0.05）, and the difference between the two groups was significant （P 〈0.05）. After treatment, compared self-conscious symptom, physical and functional status of body, daily life, social activities and total scores of quality of life scale in the observation group with that those in the control group, differences being significant（P〈0.05）. Conclusion. Fuzheng Xiaoliu tang is effective for gastric cancer and has a good inhibitive effect on VEGF of late gastric cancer patients, which is worth of clinical application.

关 键 词：胃癌 中西医结合疗法 扶正消瘤汤 血管内皮生长因子(VEGF) 免疫功能 生存质量评分 

分 类 号：R735.2[医药卫生—肿瘤]