海马益智散联合针刺治疗血管性痴呆48例临床观察  

Clinical Observation of Haima Yizhi San Combined with Acupuncture for Vascular Dementia: A Study of 48 Cases

作　　者：张瑞 王敏 陈红霞 

机构地区：[1]乌鲁木齐市中医医院脑血管科,新疆乌鲁木齐830000

出　　处：《新中医》2017年第12期142-145,共4页New Chinese Medicine

基　　金：乌鲁木齐市科学技术计划项目(C161310001)

摘　　要：目的:观察海马益智散联合针刺治疗血管性痴呆(VD)的临床疗效。方法:将96例VD患者随机分为治疗组及对照组,每组48例。对照组予降压、营养脑神经等常规西药治疗,同时予奥拉西坦胶囊口服,治疗组在对照组用药基础上予海马益智散口服,并配合醒脑开窍针法治疗,2组疗程均为3月。疗程结束后评估临床疗效,观察患者认知功能及日常生活能力的改善情况,检测治疗前后血浆脑源性神经营养因子(BDNF)及血管内皮细胞生长因子(VEGF)水平。结果:治疗组总有效率83.33%,高于对照组的64.58%,差异有统计学意义(P<0.05)。治疗后,2组简易智能精神状态检查量表(MMSE)评分及蒙特利尔认知评估量表(Mo CA)评分均较治疗前上升(P<0.05),日常生活能力量表(ADL)评分均较治疗前下降(P<0.05);治疗组的MMSE及Mo CA评分均较对照组上升更明显(P<0.05),ADL评分较对照组下降更明显(P<0.05)。治疗后,2组血清BDNF及VEGF水平均较治疗前升高(P<0.05);治疗组血清BDNF及VEGF水平均高于对照组(P<0.05)。结论:在常规西药的基础上加用海马益智散合针刺治疗VD,能有效改善患者的痴呆症状及记忆、认知功能,提高日常生活能力,提高脑神经营养水平。Objective： To observe the clinical effect of Haima Yizhi san combined with acupuncture for vascular dementia （VD）. Methods： Divided 96 cases of VD patients into the treatment group and the control group randomly, 48 cases in each group. Both groups received the routine therapy with western medicine for decompression and cranial nerve nourishment and received oral oxiracetam capsules simultaneously, while the combined with Kaiqiao Xingnao acupuncture therapy. Course treatment group additionally received Haima Yizhi san orally of treatment for both groups lasted for three months. After treatment, evaluated clinical effect, observed improvement of cognitive function and activities of daily living（ADL） of patients, and detected the levels of brain-derived neurotrophic factor （BDNF） and vascular endothelial growth factor （VEGF） before and after treatment. Results= The total effective rate was 83.33% in the treatment group, being higher than 64.58% in the control group（P 〈 0.05）. After treatment, scores of the mini-mental state examination （MMSE） and the Montreal cognitive assessment （MoCA） in both groups were increased when compared with those before treatment （P 〈 0.05）, while the scores of the ADL were decreased when compared with those before treatment （P 〈 0.05）. Increase of the scores of MMSE and VEGF in the treatment group was more significantly than that in the control group （P 〈 0.05）, and decrease of ADL scores was more significantly than that in the control group （P 〈 0.05）. After treatment, levels of serum BDNF and VEGF in both groups were higher than those before treatment （P 〈 0.05）; levels of serum BDNF and VEGF in the treatment group were higher than those in the control group （P 〈 0.05）. Conclusion： Additional application of Haima Yizhi san combined with acupuncture based on routine western medicine can effectively improve the dementia syndromes, memory and cognitive function and ADL, and promote cranial nerve nourishment for the t

关 键 词：血管性痴呆(VD) 中西医结合疗法 海马益智散 针刺 认知功能 日常生活活动能力 

分 类 号：R743.9[医药卫生—神经病学与精神病学]