去抗原猪松质骨修复犬颌骨缺损的影像学分析  

Imaging analysis of jaw defects reparation with antigen-extracted porcine cancellous bone

作　　者：陈旭锋[1] 陆丽红 冯智强[1] 殷仲达 赖仁发[1] 

机构地区：[1]暨南大学附属第一医院口腔医疗中心,广州510630 [2]东莞市人民医院口腔科,广东东莞523059

出　　处：《生物医学工程学杂志》2017年第6期883-888,共6页Journal of Biomedical Engineering

基　　金：广东省医学科研基金资助项目(A2014384);中央高校基本科研业务费专项资金资助项目(21615482)

摘　　要：目前临床应用的异种骨多来源于牛,近年来许多学者对猪骨的临床应用进行了大量的探索。因此,本研究利用去抗原猪松质骨修复狗下颌骨缺损,并进行影像学评价,为后期利用组织工程修复颌骨缺损提供新的思路。本研究通过对4只中国杂种犬施行手术,构建了双侧下颌骨骨缺损动物模型,然后采取同体双侧对照原则,随机选取一侧用犬自体骨修复(设为对照组),对侧缺损处用去抗原猪松质骨修复(设为实验组),以钛板钛钉分别予以固定,于术后第12周、第24周进行锥形束电子计算机断层扫描(CBCT)、电子计算机断层扫描(CT)和单光子发射计算机断层成像术(SPECT)检查,以SPECT与CT进行图像异机融合。研究结果显示,去抗原猪松质骨改建速度虽然较自体骨为慢,但仍可作为支架材料修复颌骨缺损。通过以上研究,本文结果或可为临床修复大面积颌骨缺损所需材料提供一种新的选择。At present, most of the bone xenograft for clinical application comes from bovine. In recent years, many studies have been done on the clinical application of porcine xenograft bone. The goal of this study was to evaluate the effect of canine mandibular defects reparation with antigen-extracted porcine cancellous bone by imaging examination. Four dogs＇ bilateral mandibular defects were created, with one side repaired with autologous bone （set as control group） while the other side repaired with antigen-extracted porcine cancellous bone （set as experimental group）. Titanium plates and titanium screws were used for fixation. Cone beam computed tomography （CBCT）, computed tomography （CT）, single-photon emission computed tomography （SPECT） were undertaken at week 12 and 24 postoperatively, and SPECT and CT images were fused. The results demonstrated that the remodeling of antigen- extracted porcine cancellous bone was slower than that of autologous bone, but it can still be used as scaffold for jaw defects. The results in this study provide a new choice for materials required for clinical reparation of jaw defects.

关 键 词：去抗原猪松质骨 颌骨缺损 电子计算机断层扫描 锥形束电子计算机断层扫描 单光子发射计算机断层成像术 图像融合 

分 类 号：R782.4[医药卫生—口腔医学]