广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性与缺血性脑卒中发病的关系  

Relationship between rs2208454 single nucleotide polymorphism of MACROD2 gene and ischemic stroke in Zhuang population of Guangxi Zhuang autonomous region

作　　者：江东东[1] 罗曼[1] 

机构地区：[1]广西医科大学第一附属医院,南宁530021

出　　处：《山东医药》2017年第43期11-13,共3页Shandong Medical Journal

基　　金：广西壮族自治区自然科学基金资助项目(2013GXNSFBA019131;2015GXNSFAA139171)

摘　　要：目的探讨广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性(SNP)与缺血性脑卒中(IS)发病的关系。方法采用SNa Pshot法对101例广西壮族IS患者(IS组)及104例健康体检者(对照组)的MACROD2基因rs2208454位点单核苷酸进行检测分析。结果两组MACROD2基因rs2208454位点GG、GT、TT基因型及G、T等位基因分布相比,P均>0.05;在显性(TT+GT和GG)、隐性(TT和GT+GG)及加性(TT和GG)三种遗传模型下,MACROD2基因rs2208454位点SNP与IS患病风险无关联(P均>0.05)。结论广西壮族人群MACROD2基因rs2208454位点SNP与IS发病可能不相关。Objective To explore the relationship between single nucleotide polymorphism（ SNP） of rs2208454 in MACROD2 gene and ischemic stroke（ IS） in Zhuang population of Guangxi Zhuang autonomous region. Methods The rs2208454 single nucleotide of MACROD2 gene was detected by SNa Pshot technique in 101 cases of Guangxi Zhuang IS patients（ IS group） and 104 healthy subjects（ control group）. Results The GG,GT,TT genotypes and G,T allele distribution of rs2208454 locus of MACROD2 gene were not statistically different between these two groups（ all P 〉 0. 05）. The rs2208454 locus SNP of MACROD2 gene was not associated with the risk of IS in dominant（ TT ＋ GT and GG）,recessive（ TT and GT ＋ GG） and additive（ TT and GG） genetic models（ all P 〉 0. 05）. Conclusion The rs2208454 locus SNP of MACROD2 gene has no correlation with the pathogenesis of IS in Guangxi Zhuang population.

关 键 词：MACROD2基因 MACROD2基因rs2208454位点 单核苷酸多态性 脑卒中 缺血性脑卒中 

分 类 号：R743[医药卫生—神经病学与精神病学]