孕晚期胎膜早破孕妇产道无乳链球菌定植与新生儿感染的相关性分析  

Correlation between neonatal infection and Streptococcus agalacticus infection of reproductive tract in women with premature rupture of membranes in late pregnancy

作　　者：林丽丽[1] 王丹[1] 戴丽芳 

机构地区：[1]温州医科大学附属第二医院产科,浙江温州325600

出　　处：《中国微生态学杂志》2017年第11期1330-1332,1339,共4页Chinese Journal of Microecology

摘　　要：目的分析孕晚期胎膜早破妇女产道无乳链球菌(SA)定植与新生儿感染之间的相关性。方法筛选2014年1月-2017年3月我院产科收治的孕晚期胎膜早破孕妇589例作为观察组,无胎膜早破的正常孕晚期孕妇261例作为对照组,对两组孕妇宫颈拭子进行细菌培养,并对其分娩的新生儿咽拭子进行细菌培养,记录两组孕妇胎膜早破合并SA阳性结果孕妇数与新生儿感染人数。结果胎膜早破孕妇宫颈拭子SA阳性率为16.47%(97/589),无胎膜早破的正常妊娠晚期妇女SA阳性率为6.13%(16/261)(P<0.01);观察组SA阳性孕妇新生儿感染发生率6.18%(6/97),显著高于本组SA阴性孕妇4.67%(23/492)(P<0.05);观察组破膜时间≥24h孕妇其新生儿感染率为62.07%(18/29),高于本组破膜时间<24h孕妇的新生儿感染率27.94%(19/68)(P<0.01);观察组产程≥24h孕妇其新生儿感染率42.42%(14/33),高于本组破膜时间<24h孕妇的新生儿感染率17.19%(11/64)(P<0.05)。结论孕晚期孕妇产道SA感染导致胎膜早破风险增加,新生儿感染率升高,有必要对SA阳性孕妇及早干预治疗,尽量减少胎膜早破,缩短产程。Objective To analyze the correlation between neonatal infection and Streptococcus agalacticus（SA）infection of reproductive tract in pregnant women with premature rupture of membranes.Methods 589 pregnant women with premature rupture of membranes were enrolled as the observation group,with 261 normally pregnant women as the control group.Cervical swabs of the two groups of pregnant women and throat swabs of their newborns were collected for bacterial culturing.The number of pregnant women with premature rupture of membranes and SA infection and the number of neonatal infections were recorded.Results The rate of SA infection in observation group was 16.47%（97/589）,significantly higher than the 6.13%（16/261）in control group（P〈0.01）.In the observation group,the incidence of neonatal infection was significantly higher among SA-positive women than among SA-negative women（6.18%vs 4.67%,P〈0.05）,significantly higher among women with rupture time≥24 hours than among those with rupture time24 hours（62.07% vs 27.94%,P〈0.01）,and significantly longer among women with stage of labor≥24 hours than among those with stage of labor24 hours（42.42%vs 17.19%,P〈0.01）.Conclusion SA infection of reproductive tract in late pregnancy leads to an increased risk of premature rupture of membranes and higher incidence of neonatal infection.It is necessary to treat SA positive pregnant women as soon as possible to minimize premature rupture of membranes and shorten the stage of labor.

关 键 词：产道感染 无乳链球菌 新生儿感染 

分 类 号：R714.2[医药卫生—妇产科学]