肿瘤短链脂肪酸代谢PET显像剂研究进展  

Progress on short-chain fatty acid tumor molecular probes for PET imaging

作　　者：张占文 胡平[2] 唐刚华[1] 

机构地区：[1]中山大学附属第一医院核医学科PET/CT中心,广州510080 [2]中山大学附属第六医院核医学科PET/CT中心,广州510655

出　　处：《国际放射医学核医学杂志》2017年第6期430-436,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81571704）

摘　　要：18F-FDG PET显像在临床上发挥着越来越重要的作用,但其在某些肿瘤的应用中存在一定的弊端,易产生假阳性和假阴性.脂肪酸代谢PET显像在脂类代谢显像中占有非常重要的地位,在一定程度上可弥补糖代谢的不足,能提高对肿瘤诊断的灵敏度和准确率.笔者就目前应用于临床前和临床研究中的肿瘤短链脂肪酸代谢PET显像剂进行综述.18F-FDG PET plays an increasingly important role in clinical assessment. However, some false-positive and false-negative results for certain tumors have been achieved with 18F-FDG. Furthermore, fatty acid metabolic imaging is valuable in lipid-metabolism PET imaging. This technique compensates for the deficiency of 18F-FDG PET examination and improves the diagnostic sensitivity and accuracy of tumor detection. This review provides an overview of recent developments in the use of short-chain fatty acid radioactive probes in PET imaging.

关 键 词：短链脂肪酸 诊断 分子探针 正电子发射断层显像术 

分 类 号：R730.44[医药卫生—肿瘤]