Immunological and virological characteristics of human immunodeficiency virus type i superinfection： implications in vaccine design  

作　　者：Yang Gao Wen Tian Xiaoxu Han Feng Gao 

机构地区：[1]Key Laboratory of AIDS Immunology of Nattonal Health and Famdy Plannmg Commtsston, Department of Laboratory Medicme, The First Affiliated Hospital, China Medical University, Shenyang 110001, China [2]National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changehun 130012, China [3]Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA

出　　处：《Frontiers of Medicine》2017年第4期480-489,共10页医学前沿（英文版）

摘　　要：Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I （HIV-1）. Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I （HIV-1）. Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关 键 词：human immunodeficiency virus type I SUPERINFECTION INCIDENCE immtme response 

分 类 号：R0[医药卫生]