Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology  

作　　者：peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang 

机构地区：[1]department of anatomy,histology and embryology,key laboratory of carcinogenesis and translational research,ministry of education,and state key laboratory of natural and biominelic drugs,peking university health science center,Beijing 100191,China [2]department of pathology,peking university health science center,Beijing 100191,China [3]institute of cardiovascular research,peking university health science center,Beijing 100191,China [4]state key laboratory of motecular oncology,national cancer center/cancer hospital,chinese academy of medical sciences and peking union medical college,Beijing 100121,China

出　　处：《Science China(Life Sciences)》2017年第11期1214-1222,共9页中国科学（生命科学英文版）

基　　金：supported by the Ministry of Science and Technology of China (2016YFC1302103, 2015CB553906. 2013CB910501);the National Natural Science Foundation of China (81230051, 81472734, 31170711, 81321003, 81301802, 30830048);Beijing Natural Science Foundation (7120002);the 111 Project of the Ministry of Education, Peking University (BMU20120314, BMU20130364);a Leading Academic Discipline Project of Beijing Education Bureau to Hongquan Zhang

摘　　要：Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that activate transmembrane receptor integrins and regulate tumor cell growth, invasion, and metastasis. Here, we report that Kindlin-1 and Kindlin-2 are differentially expressed among Chinese EC patients. For this, Kindlin-1 and Kindlin-2 expression was evaluated in 220 EC patients by immunohistochemistry （IHC） and found to be correlated with the EC progression, along with a variety of epidemiologic parameters, including smoking, family EC history, and EC invasion status. Moreover, data downloaded from the Oncomine database revealed that both Kindlin- 1 and Kindlin-2 were upregulated in ECs compared with normal esophageal tissues; although Kindlin-1 was highly expressed in well-differentiated tumors, whereas Kindlin-2 was more prevalent in poorly differentiated tumors. Collectively, these data suggest that Kindlin-1 may inhibit, while Kindlin-2 may promote, EC progression. This study, for the first time, linked the expression of Kindlin-1 and Kindlin-2 with EC family genetic background and living habits, which may help further our understanding of the various causes of EC.Esophageal cancer(EC) is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear.The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that activate transmembrane receptor integrins and regulate tumor cell growth, invasion, and metastasis. Here, we report that Kindlin-I and Kindlin-2 are differentially expressed among Chinese EC patients. For this, Kindlin-1 and Kindlin-2 expression was evaluated in 220 EC patients by immunohistochemistry(IHC) and found to be correlated with the EC progression, along with a variety of epidemiologic parameters,including smoking,family EC history,and EC invasion status. Moreover,data downloaded from the Oncomine database revealed that both Kindlin-1 and Kindlin-2 were upregulated in ECs compared with normal esophageal tissues; although Kindlin-1 was highly expressed in well-differentiated tumors, whereas Kindlin-2 was more prevalent in poorly differentiated tumors. Collectively, these data suggest that Kindlin-1 may inhibit, while Kindlin-2 may promote, EC progression. This study,for the first time, linked the expression of Kindlin-1 and Kindlin-2 with EC family genetic background and living habits, which may help further our understanding of the various causes of EC.

关 键 词：Kindlin-l Kindlin-2 esophageal cancer EPIDEMIOLOGY 

分 类 号：R735.1[医药卫生—肿瘤]