针刺结合资生汤加减治疗脾胃虚弱型慢性萎缩性胃炎的临床效果  

Clinical Study of Acupuncture Combined with Modified Zi Sheng Tang in the Treatment of Chronic Atrophic Gastritis of Spleen and Stomach Deficiency Type

作　　者：张玉红 马玲 

机构地区：[1]巩义瑞康医院,郑州451200 [2]郑州大学附属郑州中心医院,郑州450006

出　　处：《世界中医药》2017年第11期2760-2763,共4页World Chinese Medicine

基　　金：河南省重点科技攻关项目(092102310181);河南省中医药科学研究专项课题(2014ZY02060)

摘　　要：目的:观察针刺结合资生汤加减治疗脾胃虚弱型慢性萎缩性胃炎(Chronic Atrophic Gastritis,CAG)的疗效及安全性。方法:选取2014年11月至2016年10月巩义康瑞医院收治的门诊和住院脾胃虚弱型CAG患者78例,随机分为中药组和针药组,每组各39例。中药组给予资生汤加减治疗,针药组在中药组治疗基础上给予针刺胃俞、脾俞和中脘为主穴进行治疗,疗程均为49 d。观察患者治疗前后临床症状、病理检查、胃镜检查、环氧酶-1(Cyclooxygenase-1,COX-1)、谷胱甘肽-S-转移酶-π(Glutathione Stransferase-π,GST-π)和全血还原比黏度(Reductive Viscosity,RV)的变化。结果:中药组脱落1例,针药组脱落2例。治疗后针药组临床症状、病理检查、胃镜检查总有效率均高于中药组(均P<0.05);针药组GST-π、COX-1和RV评分较中药组改善更为显著(均P<0.05)。结论:针刺结合资生汤加减可有效改善脾胃虚弱型CAG患者的临床症状、GST-π、COX-1和RV,未见明显不良反应。Objective： To observe the therapeutic effect of acupuncture combined with modified Zi Sheng Tang in treatment of chronic atrophic gastritis of spleen and stomach deficiency type. Methods： A total 78 cases of chronic atrophic gastritis of deficiency of spleen and stomach type were randomly divided into Zi Sheng Tang modified group and the acupuncture combined with Zi Sheng Tang group with 39 cases in each. Treatment course lasts for 49 days. Acs-Points chosen were Weishu（ B-21）,Pi Shu,and Zhong Wan（ CV-12）. Clinical symptoms,pathological and gastroscopy examination were analyzed to estimate the efficacy of the two groups before and after treatment. The cyclooxygenase-1（ COX-1）,glutathione stransferase-π（ GST-π） and whole blood reductive viscosity（ RV） were detected. Results： One case dropped in Zi Sheng Tang group and two cases dropped in Zi Sheng Tang combined with acupuncture group. Total effect rate of improving clinical symptoms,pathological and gastroscopy indicators of the combined group is higher than those of the Zi Sheng Tang group（ all P 0. 01）. After treatment,the score of GST-π,COX-1 and RV have improved significantly（ all P 0. 05） in two groups. Conclusion： Acupuncture combined with Zi Sheng Tang is significantly effective in treating chronic atrophic gastritis of deficiency of spleen and stomach type.

关 键 词：针刺 资生汤加减 脾胃虚弱型 慢性萎缩性胃炎 

分 类 号：R573[医药卫生—消化系统]