重症肝炎患者脑组织氨基酸含量检测  

DETERMINATION OF AMINO ACID CONTENT IN DIFFERENT TISSUES OF THE BRAIN IN PATIENTS WITH FULMINANT HEPATITIS

作　　者：张捷[1] 金玉珠 徐国璋 马力[1] 董祥家[1] 

机构地区：[1]中国医科大学附属第三医院传染科 [2]沈阳市第一传染病院 [3]营口市传染病院

出　　处：《中国医科大学学报》1991年第4期288-291,共4页Journal of China Medical University

摘　　要：检测7例重症肝炎患者的大脑灰质、白质、小脑、脑桥和延髓等部位的氨基酸(AA)含量,并检测5例非因病死亡正常人的相对应脑组织氨基酸作对照。结果,重症肝炎各部位脑组织各种氨基酸含量均高于对照纽,特别是小脑和脑桥更明显增高。从各部位脑组织来看,枝链氨基酸(BCAA)与芳香族氨基酸(AAA)克分子比值,重肝患者与对照组无明显差别。提示重症肝炎,肝性昏迷的发病机理与假性神经介质形成而造成的传导障碍学说需进一步探讨。A comparative study was conducted in 7 patients with fulminant hepatitisand 5 cases of normal deaths to investigate differences in amino acid contentof different brain tissues between the two groups. Samples were taken fromthe cerebral cortex cerebral medulla, cerebellum, pous and medulla oblongata.The results showed that the concentration of virous amino acids of the patientgroup was higher than that of the control, especially the cerella and pous. Thegram-moleculer ratio of straight chain amino acid to aromatic amino-acidshowed no difference between the two group. Suggesting that further investi-gation in neededinto the heory that pseudo neuvo-transmitter are the causativeagent of hepatic coma.

关 键 词：肝炎 重症 脑组织 氨基酸 检测 

分 类 号：R512.602[医药卫生—内科学]