CFH基因，AMRS2基因和HTRA1基因的单核苷酶多态性与年龄相关性黄斑变性相关性的研究新进展  

Research progress in association of single nucleotide polymorphisms of the genes of CFH, AMRS2, and HTRA1 with age-related macular degeneration

作　　者：任立宇 张璐[1] Ren Liyu;Zhang Lu(Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科医院,150001

出　　处：《国际免疫学杂志》2017年第6期664-668,共5页International Journal of Immunology

基　　金：国家自然科学基金（81200722）;哈尔滨市科技局杰青项目（2014RFYXJ008）

摘　　要：年龄相关性黄斑变性（agerelated macular degeneration，AMD）为退行性黄斑部疾病，是50岁以上成人视力不可逆损害的主要因素之一。在它的发病机制中，遗传因素起着重要的作用。近年来，遗传学研究发现补体因子H（CFH），年龄相关性黄斑病变敏感性蛋白2（AMRS2），高温需要丝氨酸肽酶1（HTRAl）的单核苷酸多态性与AMD的发生具有显著的相关性。因此，对CFH基因和HTRA1基因的SNP与AMD的相关性进行综述，能更好认识疾病的发病机制，为疾病的评价和预测提供借鉴。Age related macular degeneration （AMD） is one of the main causes of irreversible visual impairment among people over 50 years. Genetic factors play important roles in the pathogenesis of the disease. In recent years, close correlations have been found in many studies between the occurrence of AMD and the single nucleotide polymorphisms of complement factor H （ CFH）, age-related maculopathy 2 sensitive susceptibility 2 （ARMS2） and high temperature requirement A serine peptidase 1 （ HTRA1 ）. To know research progress about the association of Single nucleotide polymorphisms of the genes of CFH,AMRS2 ,and HTRA1 with AMD is important.

关 键 词：年龄相关性黄斑变性 CFH基因 ARMS2基因 HTRA1基因 单核苷酸多态性 

分 类 号：R774.5[医药卫生—眼科]