显微镜结肠炎研究进展与现状  

Research progress and perspectives of microscopic colitis

作　　者：池肇春[1] 

机构地区：[1]青岛市市立医院消化内科,山东省青岛市266011

出　　处：《世界华人消化杂志》2017年第32期2858-2865,共8页World Chinese Journal of Digestology

摘　　要：显微镜结肠炎(microscopic colitis,MC)是慢性腹泻的常见原因.过去20年MC的流行率呈迅速增加趋势,引起了消化医师们的密切关注.MC的病因不明,免疫异常是主要的发病机制,其次是与某些药物密切相关.临床上以慢性水样、非血性腹泻、痉挛性腹痛、体质量下降与乏力为其特征,结肠镜检查正常或基本正常,但结肠活检黏膜呈炎症改变或上皮下出现胶原带增厚,作为诊断的依据.目前对MC尚无特效治疗,主要用类固醇激素布地奈德和免疫抑制剂,其他药物治疗的疗效尚不完全肯定.本病预后良好,属自限性疾病,研究指出,MC对结肠有保护作用可抵抗结直肠癌变发生,但最近研究又指出,先天免疫异常可能有致癌作用,值得今后重视与研究MC与肿瘤的相关性.Microscopic colitis（MC） is a common cause of chronic diarrhea. Over the past 20 years, the prevalence of MC has been increasing rapidly, which has aroused the close attention of digestive physicians. The etiology of MC is still unknown,and immune abnormalities are the main path-ogenesis, followed by some drugs. MC is clinically characterized by chronic non-bloody watery diarrhea, spastic abdominal pain, weight loss, and fatigue, but colonoscopy is often normal or roughly normal. Colonic biopsy often shows mucosal inflammation or subepithelial collagen band thickening, based on which a diagnosis can be made. At present, there has been no special treatment for MC, with steroid budesonide and immunosuppressive agents being the main treatments. As a self-limiting disease, MC has a good prognosis. Studies have found that MC has a protective effect against colorectal cancer. However, it was recently found that innate immune abnorm-alities may have carcinogenic effects.

关 键 词：显微镜结肠炎 非血性腹泻 胶原性结肠炎 淋巴细胞性结肠炎 

分 类 号：R574.62[医药卫生—消化系统]