磁共振弥散加权成像预测食管癌移植瘤放疗反应的实验研究  

Experimental study on radiotherapy response of esophageal cancer xenograft models by diffusion-weighted magnetic resonance imaging method

作　　者：聂梦林 王澜[1] 韩春[1] 许立昂 任雪姣[1] 刘树堂[1] 刘丽虹[1] 田华[1] 

机构地区：[1]河北医科大学第四医院放疗科,石家庄050011

出　　处：《中华放射医学与防护杂志》2017年第12期896-901,共6页Chinese Journal of Radiological Medicine and Protection

摘　　要：目的 探讨磁共振弥散加权成像（DWI）在预测食管癌放疗反应的应用价值。方法 将人食管癌Eca-109裸鼠皮下移植瘤模型按随机数表法分为实验组（14只，接受单次剂量15 Gy 6 MV X射线照射）和对照组（10只，无治疗），均在实验组照射前及之后的1、6、13 d行DWI检测。比较不同时间点两组表观弥散系数（ADC）值及体积差异。结果 两组ADC值在第1天均下降，在第6、13天时实验组逐渐升高，并高于照射前，而对照组持续下降，两组比较，差异有统计学意义（F=6.178、16.181、58.733，P〈0.05），且ADC值的变化率差异有统计学意义（F=9.038、12.360、35.140，P〈0.05）；而照射前两组ADC值差异无统计学意义（P〉0.05）。与对照组比较，移植瘤体积在照射前及照射后的前4 d差异无统计学意义（P〉0.05），从第5天开始增长明显慢于对照组（F=28.587，P〈0.05）。对照组移植瘤实验前的ADC、实验后第1天的ADC与其体积的后期变化存在线性相关关系，放疗后0～24 d，r值从-0.118逐渐升高至0.896。结论 磁共振ADC值可在食管癌移植瘤受照射后早期先于形态学发生变化，并且与肿瘤后期的体积变化存在相关关系。Objective To examine the prediction value of diffusion-weighted magnetic resonance imaging （DWI） on radiotherapy response in esophageal cancer. Methods A total of 24 subcutaneous esophageal cancer xenograft models were randomly divided into experimental group （n=14, received a single dose of 15 Gy radiotherapy） and control group （n=10, without any treatment）. MRI were required before and after radiotherapy at different check time points （1, 6, 13 days） of T1WI, T2WI, and DWI measurements. Apparent diffusion coefficient （ADCX） and volume （VX） of each xenograft were measured, and both ΔADCX and ΔVX were calculated. Results The ADC values of both group were decreased at the first day, however, the decrease in experimental group were more obviously with an increase at 6 and 13 d gradually. However, the ADC values of the control group showed a persistent decline. There was no significant difference in the ADC values between the two different groups before radiotherapy （P〉0.05）, while significant difference was found in the ADC values （F=6.178, 16.181, 58.733, P〈0.05） and ΔADC after radiotherapy （F=9.038, 12.360, 35.140, P〈0.05）. The xenografts volume in the experimental group showed a significant growth delay. There was no significant difference in volume between the two groups （P〉0.05） before radiotherapy. Significant difference in V between the two groups only began to exist at 5 d after radiotherapy （F=28.587, P〈0.05）. The ADC0, ADC1 of transplanted tumor in control group had linear correlation relationships with its volume of later period. After radiotherapy, the trend of r values gradually increased from -0.118 to 0.896. Conclusions ADC values may change significantly at the early stage after radiotherapy, and initial and early ADC value may have close relationship with xenograft volumes of later period, which indicates that DWI has huge potential in the prediction of radiotherapy response.

关 键 词：磁共振弥散加权成像 表观弥散系数 食管癌 放疗反应 裸鼠 

分 类 号：R730.55[医药卫生—肿瘤] R735.1[医药卫生—临床医学]