吸烟、饮酒对男性肝细胞癌患者肝功能及预后的影响  

Effects of smoking and drinking on liver function and prognosis in male patients with hepatocellular carcinomain

作　　者：满忠然[1] 庞青 刘会春[1] 刘昌[2] 曲凯[2] 

机构地区：[1]蚌埠医学院第一附属医院,安徽蚌埠233004 [2]西安交通大学第一附属医院,陕西西安710061

出　　处：《现代医药卫生》2017年第24期3697-3700,3703,共5页Journal of Modern Medicine & Health

基　　金：国家自然科学基金资助项目(81600452)

摘　　要：目的探讨吸烟、饮酒与男性肝细胞癌(HCC)患者临床特征及预后的关系。方法回顾性分析2002—2012年在西安交通大学第一附属医院肝胆外科住院并首次接受肝脏根治性治疗的479例男性HCC患者的临床资料及随访信息。结果吸烟与肿瘤大小、术前血清谷氨酰转肽酶(GGT)水平密切相关(P<0.05),而饮酒则与术前血清GGT及丙氨酸氨基转移酶(ALT)水平密切相关(P<0.05)。每天吸烟或饮酒的数量与上述相应参数之间存在一定的剂量依赖趋势,并具有显著相关性(P<0.05)。吸烟、饮酒可协同增加患者术前血清GGT水平,但并不显著影响HCC患者术后的总体生存率(P>0.05)。结论吸烟、饮酒可能与男性HCC患者的肿瘤大小及肝功能相关,但并不影响患者的预后。Objective To explore the association between smoking and drinking with clinical characteristics and progno-sis in male patients with hepatocellular carcinoma(HCC).Methods The clinical data and follow up information in 479 male patients with HCC receiving the liver radical therapy in the hepatobiliary department of the First Affiliated Hospital of Xi ′an Jiaotong University during 2002—2012 were retrospectively analyzed.Results Smoking was closely correlated with tumor size and preop erative serum gamma-glutamyl transpeptidase(GGT) level,while drinker was closely correlated with preoperative serum alanine transaminase(ALT) and GGT levels,the differences were statistically significant(P<0.05).The amount of smoking and drinking had a certain dose dependent trend with above parameters,and had the significant correlation(P<0.05).Smoking and drinking synergistically increased preoperative serum GGT level,but did not significantly affect the postoperative total survival rate in HCC patients(P>0.05).Conclusion Smoking and drinking may be correlated with the tumor size and liver function in male HCC pa-tients,but without affecting the patient′s prognosis.

关 键 词：吸烟 饮酒 预后 肝肿瘤 随访研究 

分 类 号：R735.7[医药卫生—肿瘤]