苄达酸的合成工艺改进  

Improvement of Synthesis Process of Bendazac

作　　者：任文杰 张文广 张利剑 郑德强 

机构地区：[1]山东省药学科学院,山东省化学药物重点实验室,山东济南250101 [2]乌鲁木齐市第一人民医院,新疆乌鲁木齐830000

出　　处：《食品与药品》2017年第6期419-421,共3页Food and Drug

摘　　要：目的改进苄达酸的合成工艺。方法以邻氨基苯甲酸为原料,经重氮化、还原、环合及N-苄基化反应,最后与氯乙酸钠缩合酸化得苄达酸。结果通过熔点测定、高效液相色谱(HPLC)、质谱、核磁共振氢谱(1H-NMR)等方法确证目标物结构。结论本工艺操作简单,避免使用剧毒物作为原料,适合工业化生产。Objective To improve the synthesis process of bendazac. Methods Bendazac was synthesized fromanthranilic acid by diazotization, reduction, cyclization, N-benzylation and condensation reaction with sodiumchloroacetate. Results The structure of bendazac was verified by melting point determination, HPLC, MS and1H-NMR. Conclusion The process is easy to operate. It avoids using poisonous material and can be applied toindustrial production.

关 键 词：苄达酸 苄达赖氨酸 工艺 改进 

分 类 号：R914.5[医药卫生—药物化学]