血管球瘤中FLi-1、h-caldesmon及collagen Ⅳ的表达及临床病理分析  

Expression of FLi-1,h-caldesmon and collagen Ⅳ in glomus tumor: a clinicopathologic study

作　　者：杨勇[1] 王瑞琳[1] 徐瑾[1] 尹海波[1] 

机构地区：[1]天津市天津医院病理科,天津300211

出　　处：《临床与实验病理学杂志》2017年第12期1337-1341,共5页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨FLi-1、h-caldesmon及collagenⅣ在血管球瘤中的表达及不同组织学类型与临床病理指标的关系。方法采用免疫组化En Vision法检测35例血管球瘤中FLi-1、h-caldesmon及collagenⅣ的表达。分析35例血管球瘤不同组织学分型与临床病理参数间的关系。结果镜下见肿瘤细胞圆形或多边形,呈片状分布在血管之间或呈环状围绕在血管周围,瘤细胞边界清晰,外形规则,有时可见瘤细胞与梭形平滑肌细胞移行过渡。免疫表型:血管球瘤可表达FLi-1、h-caldesmon及collagenⅣ,阳性率分别为58.6%、97.1%和100%。血管球瘤的不同类型与患者性别和肿瘤体积无关,与患者年龄相关(P=0.01)。35例血管球瘤中vimentin和SMA均呈(+),2例CD34呈局灶(+),1例desmin呈(+),EMA、S-100、Cg A、CD68及CD99均呈(-)。结论 h-caldesmon和collagenⅣ可作为血管球瘤诊断的标志物,FLi-1可作为一种辅助参考标志物,有助于血管球瘤的诊断。ABSTRACT Purpose To explore the expression of FLi-I, h-caldesmon and collagen 1V in glomus tumor and possible rela- tionship between different histological types and clinical-patho- logical characteristics. Methods Immunohistochemistry of En-Vision method was used to detect the expression of FLi-1, h- caldesmon and collagen IV in 35 eases of glomus tumor under microscope, and the relationship between different histological types and clinical-pathological characteristics was analyzed.Results The pathological morphology of tumor cells was round or polygonal, patchy distribution in blood vessels or arranged in a ring around the blood vessels. The tumor cell boundary was clear and the shape was regular, gradual transition between tumor cells and spindle smooth muscle cells was sometimes visible. The pos- itive rate of FLi-1, h-caldesmon and collagen IV in 35 cases of glomus tumor were 58. 6%, 97. 1% and 100% respectively. Different histological types of glomus tumors had no correlation with the sex of patient and the size of tumor, but had correlationwith the age of patient. Vimentin and SMA were positive for glo- mus tumors by immunohistochemistry in 35 cases. CD34 was positive in 2 cases. Desmin positive was found in 1 case. EMA, S-100, CgA, CD68 and CI）99 were negative. Conclusion h- caldesmon and collagen IV are the markers for glomus tumor diag- nosis, and FLi-1 can serve as a good auxiliary reference marker.

关 键 词：软组织肿瘤 血管球瘤 FLI-1 h-caldesmon collagenⅣ 免疫组织化学 

分 类 号：R739.96[医药卫生—肿瘤]