基于稀疏表示的精神分裂症生物标记物筛选方法  

A Selection Method of Biomarkers for Schizophrenia Based on Sparse Representation

作　　者：武杰[1] 魏凤仙 付令[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《中国生物医学工程学报》2017年第6期692-696,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(61101174);上海理工大学微创基金项目(YS30809153)

摘　　要：精神分裂症是以思维、情感与行为的分裂为主要特征的一类复杂精神疾病,国内外大量研究发现遗传因素是该疾病发生的重要原因。为了能够从大量影像学和遗传学数据中找出精神分裂症相关的生物标记物,受稀疏表示的启发,提出一种基于稀疏表示的影像遗传学数据整合分析方法,并应用于对精神分裂症相关生物标记物的筛选。针对从208个样本中提取到的41 236组f MRI和722 177组SNP数据,通过对传统稀疏表示模型施加广义惩罚限制,然后对两类数据施加不同的权重因子α1、α2,并且使用不同的Lp(p=0、0.5、1)范数对模型分别求解,研究不同条件下两类数据的显著关联特征规律。结果发现,基因DAOA和HTR2A在下列多重情况下均被筛选出:一是f MRI数据的权重α1取0.35~0.8之间多个不同权重时,二是SNP数据的权重α2仅为0.2时,三是在L0、L0.5、L1等3种不同范数下。此外,在影像学数据方面,发现顶下缘角回脑区也与精神分裂症相关,此发现与先前精神分裂症的影像学研究结果一致。研究结果表明,将基于稀疏表示的影像遗传学数据整合分析方法应用于精神分裂症的生物标记物筛选是一个可行的方法,这为今后精神分裂症的影像遗传学研究提供了一种新的研究思路。Schizophrenia is a complex mental disease characterized by the division of thinking,emotion and behavior. A large number of studies have found out that genetic factors are the important causes of the disease all over the world. In order to identify the biomarkers of schizophrenia from a large number of imaging genetic data,we proposed an imaging genetic data integration analysis method based on sparse representation inspired by the sparse representation,and applied it for biomarkers selection for schizophrenia. From 208 samples,41236 groups f MRI and 722177 groups SNP data were extracted. The generalized penalty restriction was applied to the traditional sparse representation model,and the weight factor α1,α2 were applied to f MRI and SNP data.With the primary aim to find out the pattern of significant association of two kinds of data under different conditions,various Lp（p = 0,0. 5,1） norm was used to solve our model. It turned out that gene DAOA and HTR2 A were selected under different situations： 1. Weight factor of f MRI α1 changed from 0. 35 to 0. 8,2.SNP weight α2 was only 0. 2,3. All three norms of Lp（p = 0,0. 5,1）. In addition,the results of imaging data suggested that Parietal_ Inf_ L and Parietal_ Inf_ R were associated with schizophrenia,which was same with previous studies of schizophrenia. The results show that the sparse representation of biomarkers selection method for schizophrenia is a feasible method; it may provide a new approach for the study of schizophrenia in the field of imaging genetics.

关 键 词：精神分裂症 稀疏表示 单核苷酸多态性 生物标记物 

分 类 号：R318[医药卫生—生物医学工程]