Luminal A型和Luminal B型乳腺癌转移的发生风险影响因素比较及分析  

A comparison of risk factors of Luminal A type and Luminal B type breast cancer with axillary lymph node metastasis and related clinical analysis

作　　者：徐国萍 何奇[1] 邵玉国[1] 籍敏[1] 

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院乳腺外科,上海200030

出　　处：《解剖学研究》2017年第6期441-445,共5页Anatomy Research

摘　　要：目的本研究就Luminal A型和Luminal B型乳腺癌腋窝淋巴结转移的临床特征进行了比较,并对相关影响因素进行初步分析。方法本研究选取我院确诊Luminal A型和Luminal B型乳腺癌患者145例进行研究,包括Luminal A型62例和Luminal B型83例。收集研究独享腋窝淋巴结转移的信息以及临床特征,并收集潜在相关影响因素信息进行分析讨论。计学处理使用SPSS 17.0统计软件。结果本研究中,Luminal A型组62例患者,Luminal B型组83例患者,两组年龄分布未见差别。Luminal A型组有16.13%患者出现腋窝淋巴结转移,Luminal B型组有39.76%患者出现腋窝淋巴结转移,Luminal B型组腋窝淋巴结转移的发生比例更高(P<0.01)。检测Luminal B型组患者HER-2表达状态结果提示总表达阳性率为21.69%;其中表达阳性的比例在腋窝淋巴结转移患者中的水平显著高于未转移的患者,HER-2阳性表达的比例分别为30.30%和16.00%(P<0.01)。年龄分布上Luminal A型和Luminal B型患者无论是否出现腋窝淋巴结转移,均未见两型患者间的年龄差异;但是在Luminal B型组患者内部,未见腋窝淋巴结转移患者年龄大于等于50岁的比例高于转移组患者;反之年龄小于50岁的比例低于转移组患者。组织学分级中Ⅰ级患者的比例在Luminal A型组为20.00%,高于Luminal B型组的9.09%(P<0.01);Ⅲ级患者比例在Luminal B型组为30.30%,高于Luminal A型组的20.00%(P<0.05);在Luminal A型组内部,腋窝淋巴结转移患者组织学分级Ⅱ和Ⅲ级的分布比例高于未转移者,而Ⅰ级的分布比例低于未转移者(P<0.01);在Luminal B型组内部分布趋势也是如此。Luminal A型和Luminal B型患者肿瘤大小分布未见差别,且均表现出2~5 cm大小的肿瘤在未见腋窝淋巴结转移的患者中比例较高(P<0.01)。对可能影响患者发生腋窝淋巴结转移的潜在相关因素进行多因素分析提示与Luminal A型患者发生腋窝淋巴结转移存在正相关的因素为病�Objective To compare the clinical characteristics of Luminal A and Luminal B breast cancer with axillary lymph node metastasis and to analyze the influential factors. Methods A total of 145 patients with Luminal A and Luminal B breast cancer were included in this study, including 62 patients with Luminal A and 83 patients with Luminal B. The information and clini- cal characteristics of axillary lymph node metastasis were collected, and the information of potential related factors were collected and analyzed. The SPSS 17.0 statistical software was used for statistical analysis. Results In the present study, there were no differ- ences in age distribution between the 62 patients in the Luminal A group and the 83 patients in the Luminal B group. Luminal A group showed axillary lymph node metastasis in 16.13% of patients, Luminal B group had 39.76% of patients with axillary lymph node metastasis, Luminal B group of axillary lymph node metastasis occurred in a higher proportion （P〈O.01）. The positive rate of HER-2 expression in Luminal B group was 21.69%. The positive expression rate of HER-2 was significantly higher in patients with axillary lymph node metastasis than that in patients with out metastatic lymph nodes, and the proportion of HER-2 positive expres- sion was 30.30% and 16.00% （P〈O.O1）. There was no difference in age between the two types of Luminal A and Luminal B patients with or without axillary lymph node metastases ; however, within the Luminal B group, no patients with axillary lymph node metasta- ses were older than 50 years of age The proportion of patients younger than 50 years of age was lower than that of the metastatic group. The proportion of grade I patients was 20.00% in Luminal A group and 9.09% in Luminal B group （P〈0.01） ; the proportion of patients in grade 111 was 30.30% in Luminal B group, which was higher than 20.00% in Luminal A group（P〈0.O1 ）. In the Lumi- nal A group, the distribution of axillary lympla node metastasis was higher in patients with grade 11 a

关 键 词：乳腺癌 分子分型 腋窝淋巴结转移 临床特征 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]