帕金森氏病相关非运动症状的研究进展  

Progression of non-motor symptoms in Parkinson's disease

作　　者：单煜恒 路美[1] 

机构地区：[1]武警后勤学院附属医院神经内科,天津300162

出　　处：《武警后勤学院学报（医学版）》2017年第9期825-828,共4页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：帕金森氏病是常见的神经系统变性疾病之一。传统研究更多关注于此病的运动症状,诸如静止性震颤、肌肉强直、运动迟缓及姿势平衡异常。近年来,关注的焦点转移至非运动症状。帕金森氏病相关的非运动症状包括有精神疾病、认知功能障碍、睡眠障碍、嗅觉障碍及自主神经功能障碍等等。这些非运动症状具有发生率高、控制效果差、降低患者生活质量等诸多特点。尽管国内外针对这一系列症状已开展大量基础及临床研究,但是此病无论是诊断标准还是治疗原则都相对欠缺。本文检索并综述近几年帕金森氏病相关的非运动症状的相关文献,旨在加深对这一疾病认识并探索今后研究方向。Parkinson＇s disease （PD） is one of common neurological degenerative diseases. Traditional research focused more on the syndromes of movement disorder in PD, such as static tremor, muscular rigidity, movement retardation and postural balance abnormality. Nowadays, highlights have shifted to non-motor symptoms （NMS）, including psychosis, cognitive impairment, sleep behavior disorder, olfactory dysfunction and autonomic dysfunction. These NMSs are of high incidence, therapy-resistance and lower quality of life. A large number of basic and clinical studies about NMS at home and abroad have increased dramatically over the last decade. However, the diagnosis or treatment principles of this disease are relatively deficient. It is our aim to review these articles, bring them into focus, expand the knowledge of NMS and consequently develop therapeutic strategies for PD patients.

关 键 词：帕金森氏病 非运动症状 认知功能障碍 精神症状 

分 类 号：R742.5[医药卫生—神经病学与精神病学]