eIF4E及其在妇科恶性肿瘤中的研究进展  

eIF4E and Its Progress in Gynecologic Malignancies

作　　者：郑楠 谭文华[1] 

机构地区：[1]哈尔滨医科大学附属第二临床医学院,150001

出　　处：《国际妇产科学杂志》2017年第6期667-670,共4页Journal of International Obstetrics and Gynecology

摘　　要：宫颈癌、子宫内膜癌和卵巢癌是女性生殖系统常见的三大恶性肿瘤,严重威胁着女性的健康。随着社会发展,生活节奏加快,恶性肿瘤发病率逐年增加。真核细胞起始因子4E(eukaryotic initiation factor 4E,eIF4E)是与恶性肿瘤的发生发展密切相关的因子,其与mRNA的5′端帽子结构特异性结合,在转录起始、翻译、细胞核内mRNA生成和细胞增殖中起重要作用,eIF4E活性受自身磷酸化、翻译抑制蛋白的磷酸化等因素调节。研究发现eIF4E在妇科恶性肿瘤中高表达,故可作为妇科肿瘤生物治疗的新靶点,协助疾病的诊断、早期预防和治疗。The three common malignant tumors of female reproductive system are cervical cancer, endometrial cancer,ovarian cancer, which are threatening the health of women. With continuous economical development of society, the pace of life is accelerating and the incidence rate of malignant diseases is increasing year by year. Eukaryotic initiation factor 4E(eIF4E) is one of the factors closely related to the occurrence and development of malignant tumors. It may specifically bind to the cap structure of mRNA 5′end and play an important role in the initiation of transcription, translation and mRNA production in cell nucleolus and cell proliferation. eIF4E activity regulated by factors such as the phosphorylation, the phosphorylation of translation inhibitory protein. The study founds that eIF4E is highly expressed in gynecologic malignancies can be expected as a new targeted biotherapy of gynecological malignant tumors, which assists in the diagnosis, early prevention and treatment of diseases.

关 键 词：真核细胞起始因子4E 生殖器肿瘤 女(雌)性 基因表达调控 肿瘤治疗方案 

分 类 号：R737.3[医药卫生—肿瘤]