调强放疗联合紫杉醇+恩度化疗对局部晚期非小细胞肺癌患者血清恶性分子含量的影响  

Effect of intensity modulated radiation therapy combined with paclitaxel + endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer

作　　者：张宏伟[1] ZHANG Hong-wei(Onccdogy Department,the First People＇s Hospital of Ziyang Sichuan Province,Ziyang City,Sichuan Province,641300)

机构地区：[1]四川省资阳市第一人民医院肿瘤科,四川资阳641300

出　　处：《海南医学院学报》2017年第20期2842-2845,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研基金资助项目(2014110089)~~

摘　　要：目的:探讨调强放疗联合紫杉醇+恩度化疗对局部晚期非小细胞肺癌患者血清恶性分子含量的影响。方法:收集2015年2月-2017年1月间在本院接受治疗的局部晚期NSCLC患者作为研究对象,经随机数表法分为对照组及研究组各59例。对照组患者接受手术后常规紫杉醇+恩度化疗,研究组患者接受手术后调强放疗联合紫杉醇+恩度化疗。对比两组患者治疗前后血清中NSCLC相关肿瘤标志物、血管新生指标含量的差异。结果:治疗前,两组患者血清中NSCLC相关肿瘤标志物、血管新生指标含量的差异无统计学意义。治疗后,研究组患者血清中TK1、CYFRA21-1、Pro-GRP、CEA、CA125、SCC-Ag的含量低于对照组患者;研究组患者血清中EGFR、COX-2、VEGF、HIF-1α、MMP-2的含量低于对照组患者。结论:局部晚期NSCLC患者术后接受调强放疗联合紫杉醇+恩度化疗,可有效降低血清恶性分子含量、优化病情。Objective：To discuss the effect of intensity modulated radiation therapy combined with paclitaxel＋ endostar chemotherapy on serum malignant molecule levels in patients with locally advanced non-small cell lung cancer.Methods：Patients with locally advanced NSCLC who were treated in the hospital between February 2015 and January 2017 were collected and divided into control group（n=59）and research group（n=59）by random number table.Control group received the routine paclitaxel＋endostar chemotherapy after the operation,and research group underwent intensity modulated radiation therapy combined with paclitaxel＋ endostar chemotherapy after the operation.The differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were compared between the two groups before and after treatment.Results：Before treatment,the differences in serum levels of NSCLC-related tumor markers and angiogenesis indexes were not statistically significant between the two groups.After treatment,serum TK1,CYFRA21-1,Pro-GRP,CEA,CA125 and SCC-Ag levels of research group were lower than those of control group;serum EGFR,COX-2,VEGF,HIF-1α and MMP-2 levels of research group were lower than those of control group.Conclusion：Postoperative intensity modulated radiation therapy combined with paclitaxel＋ endostar chemotherapy can effectively reduce the serum malignant molecule levels and optimize the illness in patients with local advanced NSCLC.

关 键 词：非小细胞肺癌 调强放疗 化疗 肿瘤标志物 血管新生指标 

分 类 号：R734.2[医药卫生—肿瘤]