奥洛他定与普拉洛芬滴眼液联合治疗对过敏性结膜炎患者免疫球蛋白、HA及ECP表达的影响  

Effects of olopatadine combined with pranoprofen eye drops on serum immunoglobulin,HA and ECP in patients with allergic conjunctivitis

作　　者：李建昌[1] 刘秀明 徐新淮[1] 

机构地区：[1]南京医科大学附属淮安第一医院眼科,江苏南京223300

出　　处：《海南医学院学报》2017年第20期2870-2872,2876,共4页Journal of Hainan Medical University

基　　金：南京卫生局基金项目(YKM1623.)~~

摘　　要：目的:观察奥洛他定滴眼液单独或联合普拉洛芬滴眼液在治疗过敏性结膜炎(allergic conjunctivitis,AC)中的临床应用,分析患者血清免疫球蛋白、组胺(HA)及嗜酸细胞阳离子蛋白(ECP)水平的变化。方法:将收治的90例AC患者按照抽签法随机分为对照组(n=45)和观察组(n=45),对照组给予奥洛他定滴眼液治疗,在此基础上,观察组加以普拉洛芬滴眼液治疗。检测所有受试者外周血免疫球蛋白、HA及ECP水平。结果:治疗前,观察组和对照组血清免疫球蛋白水平比较,差异无统计学意义(P>0.05);治疗后,观察组和对照组血清IgG、IgA和IgE水平较组内治疗前均显著降低(P<0.05),且观察组显著低于治疗后对照组,差异比较有显著性(P<0.05)。治疗前,观察组和对照组血清HA和ECP水平比较,差异无统计学意义(P>0.05);治疗后,观察组和对照组血清HA和ECP水平较组内治疗前均显著降低(P<0.05),且观察组显著低于治疗后对照组,差异比较有显著性(P<0.05)。结论:相对于奥洛他定滴眼液,奥洛他定滴眼液联合普拉洛芬滴眼液治疗AC患者,更能有效调节体液免疫功能,降低炎症反应,改善临床症状,可能是临床治疗AC患者的有效参考方案。Objective：To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis（AC）.The levels of serum immunoglobulin,histamine（HA）and eosinophil cationic protein（ECP）were analyzed.Methods：A total of 90 AC patients were randomly divided into control group（n=45）and observation group（n=45）according to the lottery method.The control group was treated with olopatadine hydrochloride eye drops.On the basis of the control group,the observation group was treated with pranoprofen eye drops.The levels of serum immunoglobulin,HA and ECP were measured in all subjects.Results：There was no significant difference in serum immunoglobulin level between the observation group and the control group before treatment（P〉0.05）.After treatment,the levels of serum IgG,IgA and IgE in the observation group and the control group were significantly lower than those before treatment（P〈0.05）.And the observation group was significantly lower than the control group after treatment（P〈0.05）.There were no significant differences in serum HA and ECP levels between the observation group and the control group before treatment（P〉0.05）.After treatment,the levels of serum HA and ECP in the observation group and the control group were significantly lower than those before treatment（P〈0.05）.And the observation group was significantly lower than the control group after treatment（P〈0.05）.Conclusion：Compared with olopatadine eye drops,olopatadine eye drops combined with pranoprofen eye drops in the treatment of AC patients,can effectively reduce the serum immunoglobulin,HA and ECP levels,which may be the clinical treatment of AC patients Of the effective reference program.

关 键 词：过敏性结膜炎 奥洛他定滴眼液 普拉洛芬滴眼液 免疫球蛋白 组胺 嗜酸细胞阳离子蛋白 

分 类 号：R777.31[医药卫生—眼科]