营养支持及干预对重度溃疡性结肠炎患者肠道菌群、Th细胞免疫应答、炎症反应的影响  

Effects of nutritional support and intervention on intestinal flora,Th cellular immune response and inflammatory response in patients with severe ulcerative colitis

作　　者：范红芬[1] 卢茸[1] 

机构地区：[1]川北医学院附属医院护士学校,四川南充637000

出　　处：《海南医学院学报》2017年第23期3223-3226,共4页Journal of Hainan Medical University

基　　金：川北医学院附属医院基金项目2013-87~~

摘　　要：目的:探讨营养支持及干预对重度溃疡性结肠炎患者肠道菌群、Th细胞免疫应答、炎症反应的影响。方法:选择2014年8月~2017年1月间在本院确诊并接受治疗的UC患者90例,经随机数表法分为对照组、营养干预组各45例。对照组患者接受UC临床常规治疗,营养干预组患者在常规治疗同时加入营养支持及干预。对比两组肠道菌群分布、Th1/Th2细胞因子含量、炎症介质含量的差异。结果:干预前,两组肠道菌群分布、Th1/Th2细胞因子含量、炎症介质含量的差异无统计学意义。干预后,营养干预组中肠杆菌、肠球菌的数量低于对照组,乳酸杆菌、双歧杆菌、丁酸梭菌的数量高于对照组;血清中IL-2、IFN-γ的含量低于对照组,IL-4、IL-10的含量高于对照组;血清中MCP-1、MIP-1a、HMGB-1的含量低于对照组。结论:重度溃疡性结肠炎患者接受营养支持及干预,可进一步均衡肠道菌群分布及Th1/Th2免疫应答,抑制全身炎症反应。Objective:To explore the effects of nutritional support and intervention on intestinal flora,Th cellular immune response and inflammatory response in patients with severe ulcerative colitis.Methods:90 UC patients who were diagnosed and treated in the hospital between August 2014 and January 2017 were divided into the control group(n=45)and the nutritional intervention group(n=45)by random number table.Control group received clinical routine therapy for UC,and nutritional intervention group received routine therapy as well as nutritional support and intervention.The differences in the intestinal flora distribution,Th1/Th2 cytokine contents and inflammatory mediator contents were compared between the two groups.Results:Before intervention,there was no statistically significant difference in the intestinal flora distribution,Th1/Th2 cytokine contents and inflammatory mediator contents between the two groups.After intervention,the number of enterobacter and enterococcus in nutritional intervention group were lower than those in control group whereas the number of lactobacilli,Bifidobacterium and clostridium butyricum were higher than those in control group;serum IL-2 and IFN-γcontents were lower than those of control group whereas IL-4 and IL-10 contents were higher than those of control group;serum MCP-1,MIP-1 aand HMGB-1 contents were lower than those of control group.Conclusion:Nutritional support and intervention can further balance the intestinal flora distribution and Th1/Th2 immune response and suppress the systemic inflammatory response in patients with severe ulcerative colitis.

关 键 词：重度溃疡性结肠炎 营养支持 肠道菌群 Th细胞免疫应答 炎症反应 

分 类 号：R574.62[医药卫生—消化系统]