Endoscopic Approach to Remove Intra-extracranial Tumors in Various Skull Base Regions： 10-year Experience of a Single Center  

作　　者：Qiu-Hang Zhang Zhen-Lin Wang Hong-Chuan Guo Feng Kong Bo Yan Ming-Chu Li Ge Chen Jian-Tao Liang Yu-Hai Bao Feng Ling 

机构地区：[1]Department of Neurosurgery, Skull Base Surgery Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Department of Otorhinolaryngology Head and Neck Surgery, Skull Base Surgery Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

出　　处：《Chinese Medical Journal》2017年第24期2933-2940,共8页中华医学杂志（英文版）

摘　　要：Background：Some problems have been found in the usually adopted combined approach for the removal of intra-extracranial tumors in skull base.Herein,we described a pure endoscopic transnasal or transoral approach （ETA） for the removal of intra-extracranial tumors in various skull base regions.Methods：Retrospectively,clinical data,major surgical complications,pre-and postoperative images,and follow-up information of a series of 85 patients with intra-extracranial tumors in various skull base regions who were treated by surgery via ETA in our skull base center during the past 10 years were reviewed and analyzed.Results：Gross total tumor removal was achieved in 80/85 cases （94.1%） in this study.All 37 cases with tumors in anterior skull base and all 14 cases with tumors in jugular foramen received total tumor removal.Thirteen and three cases with tumors in clivus received total and subtotal tumor removal,respectively.Total and subtotal tumor removal was performed for 16 cases and 2 cases in lateral skull base,respectively.The complications in this study included：cerebrospinal fluid leakage （n =3）,meningitis （n =3）,and new cranial nerve deficits （n =3;recovered in 3 months after surgery）.In the follow-up period of40-151 months （median：77 months）,seven patients （8.8%） out of the 80 cases of total tumor removal experienced recurrence.Conclusions：Complete resection of intra-extracranial growing tumors in various skull base regions can be achieved via the pure ETA in one stage in selected cases.Surgical procedure for radical removal of tumors is feasible and safe.Background：Some problems have been found in the usually adopted combined approach for the removal of intra-extracranial tumors in skull base.Herein,we described a pure endoscopic transnasal or transoral approach （ETA） for the removal of intra-extracranial tumors in various skull base regions.Methods：Retrospectively,clinical data,major surgical complications,pre-and postoperative images,and follow-up information of a series of 85 patients with intra-extracranial tumors in various skull base regions who were treated by surgery via ETA in our skull base center during the past 10 years were reviewed and analyzed.Results：Gross total tumor removal was achieved in 80/85 cases （94.1%） in this study.All 37 cases with tumors in anterior skull base and all 14 cases with tumors in jugular foramen received total tumor removal.Thirteen and three cases with tumors in clivus received total and subtotal tumor removal,respectively.Total and subtotal tumor removal was performed for 16 cases and 2 cases in lateral skull base,respectively.The complications in this study included：cerebrospinal fluid leakage （n =3）,meningitis （n =3）,and new cranial nerve deficits （n =3;recovered in 3 months after surgery）.In the follow-up period of40-151 months （median：77 months）,seven patients （8.8%） out of the 80 cases of total tumor removal experienced recurrence.Conclusions：Complete resection of intra-extracranial growing tumors in various skull base regions can be achieved via the pure ETA in one stage in selected cases.Surgical procedure for radical removal of tumors is feasible and safe.

关 键 词：Endoscopy： lntra-extracranial Growth NEOPLASM Skull Base Surgery 

分 类 号：R0[医药卫生]