肝硬化细菌感染患者血清中Presepsin检测的临床意义  

Clinical Value of Presepsin in the Diagnosis and Prognosis of Bacterial Infection in Cirrhosis

作　　者：许娜 刘永霞[1] 高莉莉[1] 王兴宁[2] 

机构地区：[1]延安大学附属医院输血科,陕西延安716000 [2]延安大学附属医院检验科,陕西延安716000

出　　处：《现代检验医学杂志》2017年第6期92-95,共4页Journal of Modern Laboratory Medicine

基　　金：陕西省延安市科技惠民计划;编号:2015HM-06-01

摘　　要：目的观察和探讨肝硬化细菌感染患者血presepsin水平的变化对疾病检测的临床意义。方法选取30例肝硬化细菌感染患者作为研究组,同期选取60例非感染肝硬化患者作为对照组。比较两组患者临床资料和血presepsin水平的差异;对比研究组存活与死亡患者血presepsin水平;应用COX多因素分析肝硬化细菌感染的预后危险因素;比较PCT,CRP与presepsin检测灵敏度及特异度。结果研究组患者血presepsin水平为1 002.3(575.1~2 149.5)pg/ml,对照组患者血presepsin水平为475.0(332.7~680.2)pg/ml,研究组患者血presepsin水平显著高于对照组,差异有统计学意义(t=1.865,P<0.05)。研究组死亡患者血presepsin水平显著高于存活患者(t=5.875,P<0.05);COX多因素分析显示presepsin水平是影响肝硬化细菌感染患者预后的独立危险因素。presepsin与CRP检测肝硬化细菌感染灵敏度和特异度相比,差异有统计学意义(P<0.05)。结论血清presepsin水平可以作为预测肝硬化细菌感染新的生物标记物,其水平明显升高可作为判断肝硬化细菌感染的一项重要指标,值得临床加以关注。Objective To observe and evaluate the clinical value of presepsin level in cirrhosis-associated bacterial infections. Methods 30 cirrhosis patients with bacterial infections were enrolled as study group. At admission, 60 cirrhosis patients without bacterial infections were enrolled as control group. The difference of blood presepsin level between two groups were analyszed and compared the relationship between level of presepsin patients. The level of presepsin of survival and death group were compared and analyszed risk factors for the prognosis of bacterial infection by COX multi-factor analysis. The sensitivity and specificity were compared by PCT,CRP and presepsin detection. Results The blood presepsin level of study group was 1 002.3（575.1 24149.5） pg/ml,the blood presepsin level of control group was 475.0（332. 74680.2） pg/ml. The presepsin of study group was significantly higher than control group, the difference was statistically significant （t = 1. 865, P〈0.05）. The presepsin level of death patients was significantly higher than survival patients （t=5. 875, P〈0.05）. COX multi-factor analysis showed that presepsin levels were independent risk factors affecting the prognosis of bacterial in fection in patients with liver cirrhosis. There were statistically significant of sensitivity and specific degrees between presep- sin and CRP （P〈0.05）. Conclusion Presepsin level is a valuable new biomarker for defining severe infections in cirrhosis. The increase of Presepsin level can be used as a judgment is an important index indicator of liver cirrhosis bacterial infection. It was worthy of clinical attention.

关 键 词：Presepsin 肝硬化 细菌感染 检测 

分 类 号：R575.2[医药卫生—消化系统] R392.11[医药卫生—内科学]