ROS在抗生素致死效应中的作用机制及其应用  

The mechanism of action of ROS in the antibiotic lethality and its applications

作　　者：娄仕高 鲁涛[1] LOU Shi-Gao;LU Tao(Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China)

机构地区：[1]云南大学云南省微生物研究所,昆明650091

出　　处：《生命科学》2017年第11期1113-1118,共6页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31660013;308-60012)

摘　　要：日益严重的细菌抗药性已成为人类健康的重要威胁,而更加全面深入地了解抗生素杀菌机制可以帮助我们更好地应对细菌抗药性问题。研究表明,ROS在抗生素的杀菌过程中起重要作用,涉及细菌胞内复杂的生理反应。现总结ROS在抗生素杀菌过程中作用机制及应用方面的一些最新研究进展,以期为寻找新的方法增强现有抗生素杀菌效果及开发新型药物提供一个新的视角。The ever-growing antibiotic resistance has posed a serious threat to human health. The comprehensive and in-depth understanding of the bactericidal mechanism of antibiotics would help us tackle the problem. Studies show that ROS play an important role in the process of antimicrobial lethality, in which complex physiological responses are involved. Herein we summarized the recent advance of studies on the mechanism and applications of ROS action during antimicrobial treatment, which would provide a new perspective for finding new ways to enhance the antimicrobial lethality of currently available antibiotics and for developing novel antibiotics.

关 键 词：ROS 抗生素 杀菌机制 

分 类 号：R978.1[医药卫生—药品]