CT引导下经皮微波消融术治疗特殊部位小肝癌36例临床研究  

Clinical observation of CT guided percutaneous microwave ablation for 36 cases of small hepatocellular carcinoma of specific lesions

作　　者：朱传东[1] 王礼学[1] 徐瀚峰[1] 童金龙[1] 郑勤[1] 丁怀银[2] ZHU Chuan- dong;WANG Li- xue;XU Han- feng;TONG Jing- long;ZHENG Qin;DING Huai-yin(Department of Oncology;Department of Radiology, the Second Hospital Affiliated, Southeast University, Nanjing 210003, China)

机构地区：[1]东南大学附属第二医院肿瘤科,江苏南京210003 [2]东南大学附属第二医院放射科,江苏南京210003

出　　处：《现代医学》2017年第11期1568-1572,共5页Modern Medical Journal

基　　金：南京市卫生局一般课题资助项目(YKK15141;YKK15142)

摘　　要：目的:回顾性分析CT引导下经皮微波消融(CT-MWA)治疗特殊部位小肝癌的临床疗效及安全性。方法:对2009年8月至2015年5月行CT-MWA治疗的36例小肝癌患者的临床资料进行回顾性分析。分析总结微波消融治疗小肝癌的1、2、3年生存率、完全消融率、局部进展率、并发症及不良反应。结果:36个小病灶行CT-MWA治疗的成功率和完全消融率分别为97.22%(35/36)和88.89%(32/36)。术后轻度肝功能异常5例,肝区疼痛轻度6例、中度3例、重度0例,恶心呕吐3例,食欲下降5例,腹胀3例,发热7例。中位局部无复发时间为15.22个月。术后3、6、12个月及1年以上的肿瘤局部进展率分别为5.56%(2/36)、5.56%(2/36)、11.11%(4/36)、19.44%(7/36)。36例患者的1、2、3生存率分别为86.67%(31/36)、58.33%(21/36)、47.22%(17/36)。结论:CT-MWA治疗特殊部位小肝癌是一种安全有效的微创治疗方法。Objective：To retrospectively analyze the clinical efficacy and safety of CT guided percutaneous microwave ablation（CT-MWA） for small hepatocellular carcinoma（HCC） with specific liver lesions.Methods：36 patients with small HCC treated with CT-MWA from August 2009 to May 2015 were collected and retrospectively analyzed.The 1-,2-and 3-year overall survival rate,complete ablation rate,local rate of progress,complications and adverse reactions were calculated and summarized.Results：The success rate of CT-MWA and complete ablation rate of 36 small lesions were 97.22%（35/36） and 88.89%（32/36）,respectively.The results of postoperative complication showed that there were 5 cases with mild liver dysfunction,6 cases with mild hepatalgia,3 cases with moderate hepatalgia,none with severe hepatalgia,3 cases with nausea and vomiting,5 cases with anorexia,3 cases with abdominal distention and 7 cases with fever.The median local recurrence time was 15.22 months.The rates of local tumor progression at 3,6,12 months and 1 years after surgery were 5.56%（2/36）,5.56%（2/36）,11.11%（4/36） and 19.44%（7/36）,respectively.The 1-,2-and 3-year survival rate of these36 patients was 86.67%（31/36）,58.33%（21/36）,and 47.22%（17/36）,respectively.Conclusion：CTMWA is a safe and effective minimally invasive treatment for small HCC of specifically located liver lesions.

关 键 词：小肝癌 微波消融术 计算机断层扫描 

分 类 号：R735.7[医药卫生—肿瘤] R730.59[医药卫生—临床医学]