大肠癌组织IGF-I、IGF-IR、GLUT-4的表达及意义  

EXPRESSION AND SIGNIFICANCE OF IGF-I,IGF-IR AND GLUT-4 IN COLORECTAL CARCINOMA

作　　者：刘晓倩 孙立园 刘莎莎[1] 赵杨[1] 申兴斌[1] 

机构地区：[1]承德医学院附属医院病理科,河北承德067000

出　　处：《承德医学院学报》2018年第1期8-11,共4页Journal of Chengde Medical University

摘　　要：目的:探讨大肠癌组织胰岛素样生长因子-I(IGF-I)、胰岛素样生长因子-I受体(IGF-IR)、葡萄糖转运蛋白-4(GLUT-4)的表达和意义。方法:应用免疫组化染色法检测70例大肠癌组织、30例大肠腺瘤和20例正常大肠黏膜IGF-I、IGF-IR、GLUT-4蛋白的表达情况,并分析大肠癌组织三者表达的相关性。结果:大肠癌组织IGF-I、IGF-IR、GLUT-4的表达明显高于大肠正常黏膜和大肠腺瘤(P<0.01);大肠癌组织中,IGF-I表达与IGF-IR和GLUT4表达呈正相关关系(r=0.412、0.396,P<0.01)。结论:IGF-I、IGF-IR、GLUT-4可能在大肠癌的发生发展过程中具有重要作用。Objective： To investigate the expression and significance of insulin-like growth factor-I（IGF-I）, insulin-like growth factor-I receptor（IGF-IR） and glucose transporter-4（GLUT-4） in colorectal carcinoma. Methods： Immunohistochemical stain was used to detect the expression of IGF-I, IGF-IR and GLUT-4 protein in 70 cases colorectal carcinoma, 30 cases colorectal adenoma and 20 cases normal colorectal mucosa; and the correlations of aboving three factors in colorectal carcinoma were also analyzed. Results： The expression of IGF-I, IGF-IR and GLUT-4 in colorectal carcinoma were significantly higher than that of normal colorectal mucosa and colorectal adenoma（P〈0.01）. In colorectal carcinoma, the expression of IGF-I was positively correlated with IGF-IR and GLUT4（r =0.412,0.396, P〈 0.01）. Conclusions： IGF-I, IGF-IR and GLUT-4 may play an important role in development of colorectal carcinoma.

关 键 词：大肠癌 胰岛素样生长因子-I 胰岛素样生长因子-I受体 葡萄糖转运蛋白-4 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]