Bmi-1在结直肠癌中的表达及其意义  

Expression and Significance of Bmi-1 in Colorectal Cancer

作　　者：曾宪清 谢晓[1] 李琰[1] 张晓勇[1] 李好朝 

机构地区：[1]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《临床研究》2018年第1期1-2,共2页Clinical Research

摘　　要：目的探讨Bmi-1在结直肠癌中的表达及其意义。方法抽取51例结直肠癌患者作研究组样本,并取30例癌旁结直肠黏膜样本作为对照A组,取30例结直肠腺瘤病理样本作为对照B组,统计三组样本的Bmi-1蛋白表达阳性率,并对不同结直肠癌分期、有无淋巴结转移的结直肠癌患者Bmi-1蛋白表达阳性率进行统计学对比。结果 (1)研究组样本的Bmi-1蛋白表达阳性率是66.67%,远高于对照A组的43.33%和对照B组的40.00%(P<0.05);(2)Dukes分期为B期者Bmi-1蛋白表达阳性率是86.67%,高于Dukes分期为C期者的61.90%(P<0.05);(3)淋巴结转移者Bmi-1蛋白表达阳性率是84.21%,高于无淋巴结转移者的53.13%(P<0.05)。结论 Bmi-1蛋白异常表达可准确反应个体结直肠癌产生、进展情况,便于临床医师准确诊断和制定合理治疗方案。Objective To investigate the expression and significance of Bmi-1 in colorectal cancer. Methods A total of 51 patients with colorectal cancer were selected as the study group. 30 cases of colorectal mucosa samples were selected as the control group A. 30 cases of colorectal adenoma were enrolled as the control group B. The positive rate of Bmi-1 protein ex-pression was compared among the three groups. The positive rate of Bmi-1 protein expression in colorectal cancer patients with different stages and lymph node metastasis was analyzed. Results The positive rate of Bmi-1 protein expression in the study group was significantly higher than that in control group A and B （66. 67% vs 43. 33% , 66. 67% vs 40. 00% , both P 〈C0. 05）. The positive rate of Bmi-1 protein expression in Dukes stage B was higher than Dukes stage C （86. 67% vs 61.90%, P〈0 . 05）. The positive rate of Bmi-1 protein expression in lymph node metastasis was higher than that in non-lymph node metastasis （84. 21 % vs 53. 13%P〈0 . 05）. Conclusion Bmi-1 protein abnormal expression can accurately reflect the formation and progress of individual colorectal cancer, which facilitates the clinician to accurately diagnose and develop areasonable treatment program.

关 键 词：nBmi-1 结直肠癌 表达 

分 类 号：R735.3[医药卫生—肿瘤]