黄连素联合阿托伐他汀对AIS病人血清MIF、MONO%及动脉硬化程度的影响  

The Effects of Berberine and Atorvastatin on Serum MIF,MONO%,and Degree of Arteriosclerosis in Patients with AIS

作　　者：李迎[1] 王佩[1] 柴美静 杨凡[1] 李红闪[1] 赵婧[1] 王欢[1] 卢丹丹[1] 

机构地区：[1]河北省保定市第一中心医院,河北保定071000

出　　处：《中西医结合心脑血管病杂志》2017年第23期3058-3061,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨黄连素联合阿托伐他汀对急性缺血性脑卒中(AIS)病人血清巨噬细胞移动抑制因子(MIF)和单核细胞比率(MONO%)及动脉硬化程度的影响。方法选择120例AIS病人,随机分为联合组(n=60)和阿托伐他汀组(n=60),均给予AIS常规治疗,联合组给予黄连素+阿托伐他汀,阿托伐他汀组给予阿托伐他汀。检测所有病人的血清MIF、MONO%水平(入院第1天、第14天)及神经功能评分(入院第1天、第14天、第90天)。所有病人给予颈部血管彩超检查(第1天、第90天)。结果两组血清MIF、MONO%水平与同时间点美国国立卫生研究院卒中量表(NIHSS)评分呈正相关(P<0.05);入院第1天,两组血清MIF、MONO%水平、NIHSS评分及动脉硬化指标比较,差异无统计学意义(P>0.05);入院第14天较第1天,两组血清MIF、MONO%水平及NIHSS评分均显著下降(P<0.05);入院第14天,联合组较阿托伐他汀组血清MIF、MONO%水平及NIHSS评分显著下降(P<0.05);第90天,联合组较阿托伐他汀组mRS评分显著偏低(P<0.05),短期预后率明显偏高(P<0.05),动脉硬化指标显著好转(P<0.05)。结论黄连素联合阿托伐他汀治疗急性缺血性脑卒中可显著降低血清MIF、MONO%水平,并降低动脉硬化程度,促进神经功能恢复,改善短期预后。Objective To investigate the effects of berberine and atorvastatin on serum macrophage migration inhibitory factor （ MIF） ,monocyte proportion （ MONO%）and degree of arteriosclerosis in patients with acute ischemic stroke （ AIS） .Methods One hundredand twenty patients with AIS were recruited and randomly divided into combined group （ n =60）and atorvastatin group （ n =60） .Allpatients received basic treatment of AIS. The patients in combined group received berberine and atorvastatin. The patients in atorvas -tatin group received atorvastatin. The levels of serum MIF, MONO%, （ day 1 and day 14）and the nerve function defect grades（ day1, day 14 and day 90）were measured.All patients received the color doppler ultrasound inspection（ day 1 and day 90） .Results There was positive correlation of serum MIF, MONO%, and National Institutes of Health Stroke Scale （ NIHSS）scores （ P 〈0.05） .The levels of serum MIF, MONO%, NIHSS, scores, and degree of arteriosclerosis were no significant relationship between combinedgroup and atorvastatin group on day 1（ P 〉0.05） .The levels of serum MIF, MONO% and NIHSS scores of the two groups on day 14were significantly lower thotin than those on day 1（ P 〈0.05） .The levels of serum MIF, MONO% and NIHSS scores of combinedgroup were significantly lower than thotin atorvastatin group’ s on day 14（ P 〈0.05） .The mRS scores of combined group were signifi-cantly lower than that in atorvastatin group’ s on day 90（ P 〈0.05） , and the degree of arteriosclerosis of combined group was signifi-cantly alleviated than that in atorvastatin group on day 90（ P 〈0.05） .Conclusion Berberine and atorvastatin can significantly downregulate the levels of serum MIF, MONO%, alleviate the degree of arteriosclerosis, improve neurological impairment in patients withAIS.

关 键 词：缺血性脑卒中 黄连素 巨噬细胞移动抑制因子 单核细胞比率 动脉硬化 美国国立卫生研究院卒中量表 

分 类 号：R743.3[医药卫生—神经病学与精神病学]