绝经前后子宫内膜癌的临床及病理特征分析  

Clinical and pathological characteristics of endometrial carcinoma in premenopausal and postmenopausal patients

作　　者：刘华[1] 建方方[1] 宋玮[1] 沈立翡[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院妇产科,上海200025

出　　处：《上海交通大学学报（医学版）》2017年第12期1670-1673,共4页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的·分析绝经前后子宫内膜癌患者的临床及病理特点。方法·回顾性分析2013年12月—2017年3月上海交通大学医学院附属瑞金医院52例绝经前和150例已绝经子宫内膜癌患者的临床病理资料。结果·未绝经组合并高血压比例为28.8%,显著低于绝经组(P<0.01);未绝经组的组织学分级G3比例为8.3%,伴深肌层浸润比例为13.5%,均显著低于绝经组(P<0.05);未绝经组累及卵巢比例高达17.6%,显著高于绝经组(P<0.05)。2组病例在合并肥胖或糖尿病、CA125、CA199、手术-病理分期、病理类型、脉管浸润、淋巴结转移等方面差异无统计学意义。结论·未绝经的子宫内膜癌患者肿瘤恶性程度相对较低,但累及卵巢的概率更大。Objective·To analyze the clinical and pathological characteristics of endometrial carcinoma patients before and after menopause. Methods·Fifty-two premenopausal cases and 150 postmenopausal cases with endometrial carcinoma from December 2013 to March 2017 in Ruijin Hospital, Shanghai Jiao Tong University School of Medicine were retrospectively analyzed. Results·The ratio of patients with hypertension in premenopausal group was 28.8%, which was significantly lower than that in postmenopausal group （P〈0.01）. In premenopausal group, the proportion of G3 in histological grading was 8.3%, and the ratio of deep myometrial invasion was 13.5%, all of which were significantly lower than those of postmenopausal group （P〈0.05）. The ratio of ovarian involvement was as high as 17.6%, which was significantly higher than that of postmenopausal group （P〈0.05）. There were no significant differences between the two groups in other clinical-pathological parameters such as obesity, diabetes, CA125, CA199, surgical-pathological staging, pathological type, vascular involvement, and lymph node metastasis. Conclusion·Premenopausal endometrial carcinoma is less malignant, while the probability of ovarian involvement is higher.

关 键 词：子宫内膜癌 未绝经 绝经 临床病理特征 

分 类 号：R737.33[医药卫生—肿瘤]