衰老过程中的表观遗传调控  

Epigenetic regulation in aging process

作　　者：豆晓阳 玄鸿文 穆永林 韩敬东[1] DOU Xiao-Yang;XUAN Hong-Wen;MU Yong-Lin;HAN Jing-Dong(Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]中国科学院-马普学会计算生物学伙伴研究所,遗传与发育协同创新中心,分子细胞卓越创新中心,计算生物学重点实验室,上海200031 [2]中国科学院大学,北京100049

出　　处：《生命科学》2017年第10期1052-1065,共14页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(31210103916,91329302,91519330);国家重点基础研究发展计划(“973”项目)(2015CB964803,2016YFE0108700)

摘　　要：生物体衰老表现为性成熟后生理功能的逐渐衰退,最终引发疾病和死亡。表观遗传调控的紊乱作为衰老的一个重要特征,暗示可以通过干预表观遗传调控来延缓衰老并治疗衰老相关疾病。现就衰老过程中的表观遗传调控的最新进展作一综述。Aging is a process with gradual loss of function and ultimately results in disease and death after sexual maturity. Disorder of epigenetic regulation has become an important feature of aging, which implies that we can delay aging and treat aging-related disease through epigenetic perturbations. Here we summarize the recent study on epigenetic regulation during aging.

关 键 词：衰老 DNA甲基化 组蛋白修饰 染色质重塑 非编码RNA 

分 类 号：Q34[生物学—遗传学] R339.38[医药卫生—人体生理学]