盐酸洛美利嗪的合成及精制  

Synthesis and Refinement of Lomerizine hydrochloride

作　　者：魏东法 王飞 

机构地区：[1]辰欣药业股份有限公司,272100

出　　处：《中国老年保健医学》2017年第6期96-97,共2页Chinese Journal of Geriatric Care

摘　　要：目的优化工艺合成精制盐酸洛美利嗪。方法以2,3,4-三甲氧基苯甲醛与双-(4-氟苯基)甲基哌嗪为起始物料反应生成盐酸洛美利嗪。结果经过工艺优化,收率达到73.5%。所得产品结构经1H-NMR,MS,元素分析确证。粗品经过精制,纯度更高。结论本工艺适合工业生产且纯度较高。Objectives To synthesize and Refinement lomerizine hydrochloride. Methods The reaction of 2,3,4- tri methoxy benzaldehyde and double -（4-fluoro phenyl） methylpiperazine as the starting material to produce lomeizine hydrochloride. Results The reaction was modified and improved, theyield was 73.5%. The structure of title compound was confirmed by 1H-NMR, MS and elemental analysis data. The crude product is refined and the purity is higher. Conclusion The process can be easily controlled and has high purity.

关 键 词：盐酸洛美利嗪 合成精制 纯度 

分 类 号：R914[医药卫生—药物化学]