DRD2基因rs1800497多态性与精神分裂症发病和认知功能的关系  

Relationship between rs1800497 polymorphism of DRD2 gene and pathogenesis and cognitive function of schizophrenia

作　　者：徐晓文[1] 惠李[1] 谷晓楚[1] 吴兢勤 钱志平[1] 孙洪言 潘名志[1] 陈洁 朱宏亮[1] 王小琼[2] 尹晓莉 台勇[2] 

机构地区：[1]苏州大学附属广济医院,江苏苏州215137 [2]温州医科大学附属康宁医院精神科,浙江温州325000

出　　处：《中国现代医生》2017年第34期1-3,6,共4页China Modern Doctor

基　　金：国家自然科学基金项目(81771439);国家自然科学基金项目(81501160);江苏省青年医学人才(QNRC2016228)

摘　　要：目的调查多巴胺D2受体(DRD2)基因rs1800497多态性与慢性精神分裂症发病和认知功能的关系。方法招募567例慢性精神分裂症患者和421例健康受试者,认知功能采用重复性成套神经心理状态测验量表(RBANS)评估,DRD2基因rs1800497多态性采用Taq Man SNP方法进行基因分型为:C/C、C/T、T/T。收集一般人口学和临床数据。结果慢性精神分裂症组和健康对照组DRD2基因rs1800497位点的等位基因频率的分布没有显著性差异(χ~2=0.05,df=1,P=0.83),但基因型频率的分布出现显著性差异(χ~2=7.00,df=2,P=0.03)。精神分裂症患者依据rs1800497位点基因型分组分析:组间延迟记忆分值出现显著差异(F=3.91,P=0.02)。结论DRD2基因rs1800497位点可能参与了精神分裂症的发病,并进一步可能影响精神分裂症的认知功能。Objective To investigate whether rs1800497 polymorphism of Dopamine D2 receptor（DRD2） gene associated with the onset and cognitive function of chronic schizophrenia. Methods A total of 567 patients with chronic schizophrenia and 421 healthy subjects were enrolled in this study. Cognitive function was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status （RBANS）. The rs1800497 polymorphism of DRD2 gene was genotyped by TaqMan SNP method as follows： C/C, C/T, T/T. The general demographic and clinical data were collected. Results There was no significant difference in allele frequencies of rs1800497 in the DRD2 gene between the chronic schizophrenia group and the healthy control group（χ^2=0.05, dr=1, P=0.83）. But there was a significant difference in the distribution of genotype frequencies（χ^2=7.00, df=2, P=0.03）. Schizophrenia patients were grouped and analyzed according to rs1800497 locus genotypes. There was a significant difference in delayed memory scores between groups（F=3.91, P=0.02）. Conclusion The rs1800497 site of DRD2 gene may be involved in the pathogenesis of schizophrenia and may further affect the cognitive function of schizophrenia.

关 键 词：精神分裂症 DRD2基因 认知功能 rs1800497 

分 类 号：R749.3[医药卫生—神经病学与精神病学]