CHCHD2在非小细胞肺癌中的表达及临床意义  

Expression and clinical significance of CHCHD2 in non-small cell lung cancer patients

作　　者：杨锋[1] 夏靖华[1] 孙盈[1] 王雪娇[1] 文苗苗[1] 李小飞[1] 张志培[1] 

机构地区：[1]第四军医大学唐都医院胸腔外科,西安710038

出　　处：《临床与病理杂志》2017年第11期2345-2351,共7页Journal of Clinical and Pathological Research

摘　　要：目的:检测CHCHD2在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织和相应正常组织中的表达,探讨其在NSCLC发生发展过程中的可能作用及临床意义。方法:收集209例NSCLC组织,采用免疫组织化学法检测NSCLC及相应正常组织中CHCHD2的表达,分析其在临床病理因素中的差异性。结果:CHCHD2主要定位于细胞质中,癌组织与正常组织中表达阳性率差异有统计学意义(P<0.001)。CHCHD2在鳞癌亚型间表达差异无统计学意义(P=0.957);在腺癌亚型间表达差异有统计学意义(P=0.027);在腺癌、鳞癌的病理分级间,表达差异均有统计学意义(P=0.009,P=0.006);在TNM分期的T分期和N分期中表达差异有统计学意义(P=0.011,P<0.001)。结论:CHCHD2在NSCLC中高表达,是NSCLC组织与相应正常组织表达的差异蛋白,其高表达可能会促进NSCLC的发展、侵袭和转移,有望成为NSCLC不良预后的指标。Objective： To detect the expression of CHCHD2 in non-small cell lung cancer（NSCLC） and normal tissues, and investigate its role and clinical significance on the process of NSCLC. Methods： The expression of CHCHD2 in NSCLC tissues and paired normal tissues of 209 cases was detected by immunohistochemistry method. The difference of CHCHD2 expression in clinicopathological parameters were analyzed by statistics. Results： Positive staining of CHCHD2 was mainly in cytoplasm. The positive expression rates of the CHCHD2 protein in NSCLC tissues was significantly higher than that in normal tissues（P〈0.001）. In SCCs, no significant difference was found that CHCHD2 expression among different subtypes（P=0.957）. However, in ADCs there were significant difference of CHCHD2 expression in different subtypes（P=0.027）. The expression of CHCHD2 was significant difference among groups of pathological grading groups of SSCs and ADCs（P=0.009, P=0.006）. There were significant difference of the CHCHD2 expression among various groups of T and N clinical stages（P=0.011, P〈0.001）. Conclusion： CHCHD2 is over-expressed in NSCLC and differentially expressed proteins between NSCLC tissues and normal tissues. CHCHD2 over-expressed in NSCLC, might promote the development, invasion and metastasis of NSCLC, which is expected to be a prognostic indicator for NSCLC.

关 键 词：非小细胞肺癌 CHCHD2 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]