PCF和DCF治疗进展期胃癌的临床分析  

Clinical Analysis Between PCF and DCF in Treatment of Advanced Gastric Cancer

作　　者：卢玮冬[1] 左云[1] 许震[1] 张敏[1] 陈志鹏[1] 王少开[1] LU Wei-dong;ZUO Yun;XU Zhen;ZHANG Min;CHEN Zhi-peng;WANG Shao-kai(Department of Oncology, Zhangjiagang First People＇s Hospital, Zhangjiagang, Jiangsu, 215600, China)

机构地区：[1]张家港市第一人民医院,苏州大学附属张家港医院肿瘤科,江苏张家港215600

出　　处：《中国血液流变学杂志》2017年第2期177-179,207,共4页Chinese Journal of Hemorheology

摘　　要：目的 探究PCF和DCF两种化疗方案治疗进展期胃癌的疗效及副作用.方法 回顾性分析2010年1月—2014年1月就诊的进展期胃癌患者45例的病历资料,根据化疗方案不同分为研究组（n=25）和对照组（n=20）,研究组采用PCF（紫杉醇脂质体＋氟尿嘧啶＋奥沙利铂）方案;对照组采用DCF（多西他赛＋氟尿嘧啶＋奥沙利铂）方案.对比两组患者化疗的疗效及副作用.结果 研究组的总有效率为72.0%,对照组为65.0%,差异无统计学意义（P〉0.05）.研究组化疗后生活质量增加的比例（40.0%）高于对照组（15.0%）,差异有统计学意义（P〈0.05）.研究组Ⅲ度消化道反应（4.0%）和Ⅲ度骨髓抑制的比例（28.0%）低于对照组（25.0%和55.0%）,差异均有统计学意义（P〈0.05）.研究组2年生存率（84.0%）高于对照组（60.0%）,差异有统计学意义（P〈0.05）.结论 对于进展期胃癌患者,PCF与DCF两种化疗方案效果相当,然而前者副作用较小,安全性高,值得临床推广.Objective To compare the clinical effect between PCF and DCF in treatment of advanced gastric cancer. Methods 45 patients with advanced gastric cancer treated in our hospital from Jan. 2010 to Jan. 2014 were selected. They were divided into research group （n=25） and control group （n=20） according to different chemotherapy methods. The research group was given chemotherapy method of PCF （paclitaxel liposome＋ fluorouracil ＋ oxaliplatin）, and the control group was given chemotherapy method of DCF （docetaxel ＋fluorouracil ＋ oxaliplatin）. The clinical effect and side effect was compared between two groups. Results There was no significant difference in effective rate between two groups （72.0% vs 65.0%） （P〉0.05）. The proportion of life quality increasing of research group （40.0%） was higher than that of control group （15.0%） （P〈0.05）. The proportions of degree Ⅲ digestive tract reaction and degree Ⅲ myelosuppression of research group （4.0%, 28.0%） were lower than those of control group （25.0%, 55.0%） （P〈0.05）. The 2 year survival rate of research group （84.0%） was higher than that of control group （60.0%） （P〈0.05）. Conclusion As for patients with advanced gastric cancer, the effect of PCF and DCF chemotherapy regimens is equivalent, but side effects is small, and of the former it is worthy of clinical promotion.

关 键 词：胃癌 紫杉醇脂质体 多西他赛 疗效 副作用 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]