血浆脂蛋白磷脂酶A2、同型半胱氨酸与急性脑梗死患者病情严重程度及血脂水平的相关性分析  

Correlation Analysis Between Plasma Lipoprotein Phospholipase A2,Homocysteine and Severity and Level of Blood Lipid in Patients with Acute Cerebral Infarction

作　　者：黄玉静[1] 吴正刚[1] 黄晶[1] 王璐[1] 李玲[1] 

机构地区：[1]泰州市人民医院神经内科,江苏泰州225300

出　　处：《现代生物医学进展》2017年第35期6909-6912,共4页Progress in Modern Biomedicine

摘　　要：目的:研究血浆脂蛋白磷脂酶A2(Lp-PLA2)、同型半胱氨酸(Hcy)与急性脑梗死患者病情严重程度及血脂水平的相关性。方法:选取2016年5月至2017年6月我院收治的急性脑梗死患者140例为观察组,同期健康体检者140例为对照组。分别检测两组研究对象的血浆Lp-PLA2、Hcy以及血脂指标水平,并作相关性分析。根据观察组患者神经功能缺损程度评分(NIHSS)并将其分为轻型组60例,中型组55例以及重型组25例,对比三组患者的血浆Lp-PLA2、Hcy水平。结果:观察组血浆Lp-PLA2、Hcy水平以及甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平较对照组高,而高密度脂蛋白胆固醇(HDL-C)水平较对照组低,差异均有统计学意义(均P<0.05)。经Pearson相关性分析可得:血浆Lp-PLA2、Hcy与HDL-C均呈负相关关系(r=-0.593、-0.701,均P<0.05),而与LDL-C均呈正相关关系(r=0.576、0.672,均P<0.05)。重型组、中型组患者Lp-PLA2、Hcy水平显著高于轻型组,同时重型组患者Lp-PLA2、Hcy水平显著高于中型组,差异均有统计学意义(均P<0.05)。结论:血浆Lp-PLA2、Hcy水平与急性脑梗死患者的HDL-C均呈负相关关系,与LDL-C均呈正相关关系。且随着患者病情越严重,血浆Lp-PLA2、Hcy水平越高。Objective： To study the correlation analysis between plasma lipoprotein phospholipase A2 （Lp-PLA2）, homocysteine （Hey）and the severity and the level of blood lipid in the patients with acute cerebral infarction. Methods： A total of 140 patients with acute cerebral infarction, who were treated in Taizhou People＇s Hospital from May 2016 to June 2017, were chosen as observation group; 140 healthy subjects were enrolled as control group at the same time. The levels of plasma Lp-PLA2, Hey and serum lipids in the two groups were detected respectively and made a correlation analysis. The observation group were further divided into light group （n=60）, medium size group（n=55） and heavy group（n=25） according to the degree of neurologic impairment （NIHSS）. The levels of plasma Lp-PLA2 and Hcy were compared among the three groups. Results： The levels of plasma Lp-PLA2, Hcy, triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） ofthe observation group were higher than those ofthe control group, the level of high-density lipoprotein cholesterol （HDL-C） was lower than that of the control group, the differences were statistically significant （all P〈0.05）. Pearson correlation analysis showed that the levels of plasma Lp-PLA2 and Hey were negatively correlated with HDL-C （r=-0.593, -0.701, all P〈0.05）, but positively correlated with LDL-C （r=0.576, 0.672, all P〈0.05）. The levels of Lp-PLA2 and Hcy in the heavy group and medium-sized group were significantly higher than those in the light group, the Lp-PLA2 and Hcy levels in the heavy group were significantly higher than those in the medium-sized group, the differences were statistically significant （all P〈0.05）. Conclusion： The levels of plasma Lp-PLA2 and Hcy were negatively correlated with HDL-C in the patients with acute cerebral infarction, and positively correlated with LDL-C. The more severe the patient＇s condition, the higher the levels of plasma Lp-PLA2 and Hey.

关 键 词：急性脑梗死 脂蛋白磷脂酶A2 同型半胱氨酸 血脂 相关性 

分 类 号：R743[医药卫生—神经病学与精神病学]