细胞增殖核抗原KI-67在复发胶质瘤中表达水平的变化分析  

Analysis of Changes of the KI-67 Expressing in Recurrent Glioma

作　　者：张达旻 朱正权[1] 刘亮[1] 杜山别克.克孜 夏海成[1] 

机构地区：[1]新疆医科大学附属肿瘤医院神经外科,乌鲁木齐830011

出　　处：《新疆医学》2017年第11期1272-1274,共3页Xinjiang Medical Journal

摘　　要：目的通过研究复发胶质瘤与初发胶质瘤肿瘤组织中细胞增殖核抗原KI-67表达水平的变化,了解胶质瘤复发后肿瘤的侵袭性的变化规律。方法回顾性分析免疫组化发检测的20例复发胶质瘤患者的首次手术及复发后再次手术的胶质瘤组织中KI-67表达水平,自身前后配对设计t检验;两次手术间隔时间与KI-67之间相关性以Pearson相关分析。结果复发胶质瘤肿瘤组织中KI-67较首次手术肿瘤组织的明显增加,差异具有统计学意义(P<0.05),两次手术间隔时间与KI-67变化幅度无明确相关性(P>0.05)。结论本研究表明:复发胶质瘤的侵袭性较初发胶质瘤明显增高且增高的幅度不受两次手术间隔时间影响。Objective To find the invasive changing regulation of the tumor after recurrence by studying the change of KI-67 expression level in the tumor tissues of recurrent glioma and original glioma. Methods Analyze the KI-67 expression level retrospectively in the glioma tissues which got fromthe first and second surgeries from the 20 cases of patients, the expressing of KI-67 was tested by immunohistochemical detection, and the t-test of matching design was used before and after, Pearson correlation analysis was used to find the correlation between the interval time of the two operations and KI-67 expression. Results KI-67 in the recurrent glioma tumor increased significantly than in the tumor tissue of the first surgery, the difference was statistically significant（P 0.05）, there was no clear correlation between the interval time of the two operations and the changing range of KI-67（P 0.05）. Conclusion This study shows that the invasiveness of recurrent glioma increased significantly than the original glioma, and the increasing range is not influenced by interval time between the two surgeries.

关 键 词：复发 胶质瘤 KI-67 

分 类 号：R730.246[医药卫生—肿瘤]