纱布挥发法吸入麻醉在大鼠气管插管操作中的应用  

The Application of Inhalation Anesthesia Volatilized from Gauze in Tracheal Intubation in Rats

作　　者：王泽文 常路[2] 肖晓山[2] 潘晓燕 舒海华[2] 

机构地区：[1]广东医科大学,广东广州524023 [2]广东省第二人民医院,广东广州510317

出　　处：《现代医院》2017年第12期1800-1803,共4页Modern Hospitals

基　　金：国家自然基金(编号:81571071);广东省自然科学基金(编号:2014A030313203)

摘　　要：目的对比不同方式的吸入麻醉诱导在大鼠气管插管中的应用。方法 36只SD大鼠随机分为6组,每组各6只,1.2 mL七氟烷纱布挥发组(1.2S组)、0.6 mL七氟烷纱布挥发组(0.6S组)、0.8 mL异氟烷纱布挥发组(0.8I组)、0.4 mL异氟烷纱布挥发组(0.4I组)、7.5%七氟烷挥发罐挥发组(S组)和5%异氟烷挥发罐挥发组(I组)。大鼠置于麻醉箱中诱导后气管插管,若第一次插管失败,则进行二次操作;二次插管失败则放弃操作。记录首次诱导时间、首次插管时间、二次诱导时间、二次插管时间,计算累计诱导时间(T1)、累计插管时间(T2)、累计诱导插管总时间(T3)、一次成功率、操作即时死亡率及操作24 h后死亡率。结果 1.2S组、0.6S组和0.8I组的诱导插管总时间差异性无统计学意义(P>0.05),且均小于0.4I组、S组及I组(P<0.05),0.4I组诱导插管总时间小于S组(P<0.05),S组诱导插管总时间小于I组(P<0.05)。1.2S组、0.6S组和0.8I组的一次插管成功率高于其他组。结论1.2 mL、0.6 mL七氟烷及0.8 mL异氟烷经纱布挥发诱导可更好地达到大鼠气管插管的麻醉需求。Objective To compare different approaches of inhalation anesthesia in tracheal intubation in rats. Meth- ods 36 SD rats were randomly assigned into six groups （n =6 for each group）. All rats were put in a plexiglass - box aml 1.2 mL sevoflurane volatilized from cotton gauze （ group 1.2 S） , 0. 6 ml sevoflurane volatilized fi＇om gauze （ group 0. 6S ） , 0. 8 mL volatilized from gauze isoflurane group （ group 0. 81） , 0. 4 mL isoflurane volatilized from gauze （ group 0. 41） , 7.5% sevoflurane volatilized from vaporizers （group S） , 5% isoflurane vaporize group （group I） were inhaled for induction, re- spectively. Second procedure was carried out if the first intubation was failed. Time of first and second （ if any） induction and tracheal intubation were recorded and cumulative time of induction （TI） , tracheal intubation （T2） , overall operation （T3） were calculated. One - time intubation success rate, immediate mortality and the mortality of 24h after operation were recor- ded. Results There was no significant difference of T3 among the groups 1.2S, 0. 6S and 0. 8I （P 〉 0. 05）. T3 was signifi- cantly shorter in groups 1.2S, 0. 6S and 0. 8I than in groups 0. 4I and S （P 〈 0. 05）. T3 was significantly shorter in group 0.4I than in group S （P 〈0.05）. The one - time intubation success rate, both of＂ 1.2S group, 0. 6S group and 0.8[ group, were higher than the other groups. Conclusion Gauze volatile anesthesia can induce rat tracheal intubation more efficiently.

关 键 词：吸入麻醉 大鼠 气管插管 纱布挥发法 

分 类 号：R-332[医药卫生] R614