加味五虎汤联合阿奇霉素治疗痰热闭肺型小儿支原体肺炎疗效及对T淋巴细胞亚群的影响  

Efficacy of Modified Wuhutang Combined with Azithromycin in Treating Children with Phlegm Heat Closed Lung Type Mycoplasma Pneumonia and Its Effect on T Lymphocyte Subsets

作　　者：边红恩 陈团营 单海军 

机构地区：[1]河南中医药大学第二附属医院

出　　处：《中国实验方剂学杂志》2018年第2期164-169,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省基础与前沿技术研究计划项目(142300410070);河南省科技攻关计划项目(0324420083);河南中医学院科技创新团队支持计划项目(2010XCXTD11)

摘　　要：目的：探讨加味五虎汤联合阿奇霉素治疗痰热闭肺型zJ,JL支原体肺炎的临床疗效，及对T淋巴细胞亚群的影响。方法：研究对象为2015年1月-2017年2月河南中医药大学第二附属医院收治的150例痰热闭肺型小儿支原体肺炎患儿，采取随机数字表将其分成两组，每组75例。两组患儿均给予阿奇霉素治疗，观察组联合给予加味五虎汤治疗，比较两组临床疗效以及治疗前后T淋巴细胞亚群、炎性细胞因子变化情况。结果：经14d治疗后，观察组总有效率达98．67％，对照组总有效率为88．00％，观察组优于对照组（P〈0．01）。观察组患儿干湿哕音、咳嗽消失时间以及退热时间较对照组患儿均有缩短（P〈0．01）。经14d治疗后，两组CD4＋水平，CD4＋／CD8＋均有明显上升（P〈0．01），与对照组治疗后比较，观察组CD4＋水平，CD4＋／CD8＋升高更显著（P〈0．01）；观察组CD8＋水平有显著下降（P〈0．01），对照组无明显变化。两组患儿在治疗14d后血清白细胞介素-6（IL-6），白细胞介素-8（IL-8），肿瘤坏死因子（TNF）-α水平相对于治疗前有明显降低，但与对照组治疗后比较，观察组上述血清炎性因子水平降低更显著（P〈0．01）。两组治疗过程中均未发生明显的药物不良反应，且观察组不良反应发生率显著低于对照组（P〈0．01）。结论：加味五虎汤联合阿奇霉素治疗痰热闭肺型小儿支原体肺炎能有效减轻患儿机体内炎症反应，提高免疫功能，疗效确切。Objective： To explore the efficacy of modified Wuhutang combined with azithromycin in treating children with phlegm heat closed lung type mycoplasma pneumoniaand and its effect on T lymphocyte subsets. Method： A total of 150 children with phlegm heat closed lung type myeoplasma pneumonia treated at our hospital from January 2015 to February 2017 were selected as research objectives and randomly divided into two groups, with 75 cases in each group. Azithromyein was provided to both groups; besides, modified Wuhutang was additionally administered to observation group. The two groups＇ clinical efficacy, T lymphocyte subsets and inflammatory cytokines before and after treatment were compared. Result： After 14 days of treatment, observation group＇s total effective rate was 98.67% , which was significantly higher than 88.00% of control group （P 〈 0.01 ）. Observation group＇s dry and wet rules, cough disappearance time and fever time were significantly shorter than those in control group （P 〈 0. 01 ）. After 14 days of treatment, the two groups＇ CIM＋ level, CD4＋/CD8＋ increased significantly （P 〈 0.01 ）, particularly in observation group （P 〈 0.01 ）. Observation group＇s CD8＋ level decreased significantly （P 〈0. 01 ） , but there was no obvious change in control group. The two groups＇ serum interleukin-6, interleukin-8, tumor necrosis factor-a after 14 day of treatment was significantly lower than those before treatment, particularly in observation group （P 〈 0. O1 ）. There was no significant adverse drug reaction in the two groups, and the incidence of adverse reactions in observation group was significantly lower than that in control group （P 〈 0. 01 ）. Conclusion： Modified Wuhutang combined with azithromycin can effectively reduce inflammatory response and improve immune function of children with phlegm heat closed lung type mycoplasma pneumonia.

关 键 词：加味五虎汤 阿奇霉素 小儿支原体肺炎 痰热闭肺型 T淋巴细胞亚群 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]