糖尿病肾病的炎症致病机制与中药防治  

Pathogenic Mechanism of Inflammation and TCM Intervention of Diabetic Nephropathy

作　　者：王永胜[1] 杨丽霞[1] 程涛[1] 王振华[1] 孟祥云 周思彤[2] 

机构地区：[1]甘肃省中医药研究院,兰州730050 [2]甘肃省中医院,兰州730050

出　　处：《中国实验方剂学杂志》2018年第2期200-207,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81560764);甘肃省中医药管理局科研课题项目(GZK-2015-32)

摘　　要：糖尿病肾病（diabetic nephropathy，DN）是糖尿病患者的重要慢性并发症之一，其最主要的特征是糖尿病。肾小球细胞的硬化，1型和2型糖尿病均有一定概率并发糖尿病肾病，发展到最后导致肾脏坏死。糖尿病患者的生命健康直接受到糖尿病肾病的严重威胁，由于现代医学技术的快速发展，各种治疗手段的出现使糖尿病患者死于酮症酸中毒的情况越来越少，目前导致糖尿病患者死亡的主要原因是糖尿病的各种并发症，例如糖尿病肾病及糖尿病引起的心血管疾病。糖尿病患者微血管慢性并发症中最重要的是DN，DN也是糖尿病患者致死的重要因素之一。炎症反应过程在DN的发生发展中发挥着非常重要的作用。糖尿病肾病与其炎症反应机制关系十分密切。目前，糖尿病肾病的相关综述已有部分报道，有研究发现糖尿病肾病的相关炎症因子主要有C-反应蛋白，转化生长因子嵋等，DN的炎症信号通路有核转录因子（NF）-xB和丝裂原活化蛋白激酶（MAPK）信号转导通路等，中药对于DN的防治有着较好的防治作用。但是缺乏关于DN炎症致病机制与中药防治详细且系统的总结。本文就DN的炎症致病机制与中药防治方面的内容进行整理后做一综述，以期为DN的早期预防及后期干预治疗提供一定参考。Diabetic nephropathy （DN） is one of the important chronic complications of diabetic patients Because the most important feature of diabetic is glomerular cell sclerosis, type 1 and type 2 diabetes have a certain probability of suffering from DN, which may finally develop to kidney necrosis. Life and health of diabetic patients are directly threatened by DN. Benefited from the rapid advance of modern medical technology, fewer and fewer diabetic patients died of ketoacidosis. Currently, the main cause for diabetes deaths is various complications of diabetes, such as DN and cardiovascular disease caused by diabetes. DN is the most serious chronic microvascular complication for diabetic patients, as well as one of important causes for the death of DN. The inflammatory response process plays a very important role in the development and progress of DN. At present, many studies have reported relevant reviews of diabetic nephropathy, finding that diabetic nephropathy-associated inflammatory factors mainly include C-reactive protein, transforming growth factor-β, DN, inflammatory signaling pathway nuclear factor （NF） -KB signal transduction pathway and mitogen-activated protein kinase （MAPK） signal transduction pathway. This paper summarizes the pathogenesis of DN and the prevention and treatment with traditional Chinese medicine, in order to provide a reference for early prevention of DN and later intervention and treatment.

关 键 词：糖尿病 糖尿病肾病 炎症致病机制 中药 

分 类 号：R22[医药卫生—中医基础理论] R2-031[医药卫生—中医学]