丹参多酚酸对急性脑梗死患者血清胆红素、hs-CRP水平的影响及临床疗效观察  

The effect of salvianolic acids on the levels of bilirubi, hs-CRP in patients with acute cerebral infarction and clinical observation

作　　者：卢军栋[1] 苏鹏[1] 王铮[1] 张欣[1] 

机构地区：[1]保定市第一中心医院神经内科,河北071000

出　　处：《脑与神经疾病杂志》2018年第1期35-39,共5页Journal of Brain and Nervous Diseases

摘　　要：目的探讨丹参多酚酸对急性脑梗死(ACI)患者血清胆红素、超敏C反应蛋白(hs-CRP)水平的影响。方法将80例ACI患者随机分为丹参多酚酸治疗组和常规治疗组,观察血清胆红素、hsCRP水平、美国国立卫生研究院卒中量表(NIHSS)评价神经功能缺损程度。结果与治疗第1天相比,治疗第14天时丹参多酚酸组患者胆红素水平降低(P=0.003),NIHSS评分降低(P=0.000);治疗第14天时,丹参多酚酸组患者血清胆红素水平高于对照组(P=0.003),NIHSS评分低于照组(P=0.000)。hs-CRP与血清胆红素呈负相关。结论丹参多酚酸治疗ACI效果明显,其机制可能与减少炎症反应、抗氧化有关,有临床应用价值。Objective To investigate the effect of salvianolic acids on the bilirubi level, hypersensitive c-reactive protein （ hs-CRP ） level and clinical outcomes of patients with acute cerebral infarction （ ACI ） . Method A total of eighty patients with ACI were randomly divided into two groups： treatment group and control group. Patients in treatment group were given salvianolic acids and those in control group were given conventional treatment. We observed the efficacy and the change of hs-CRP and bilirub in two groups, and National Institutes of Health Stroke Scale （ NIHSS ） was used to evaluate neurological functional defect. Results After 14 day treatment, the levels of bilirubi, hs-CRP in treatment group was significantly decreased （ P=0.003 ） , and NIHSS score was significantly reduced （ P=0.000 ） ; comparing with control group, the level of salvianolate was significantly higher （ P=0.003 ）, while NIHSS score was significantly lower （ P=0.000 ） . hs-CRP was negatively correlated with bilirubin. Conclusion Salvianolic acids can promote the recovery of neurologicalfunction in patients with acute cerebral infarction, which may be related to decreasing the resistance to antioxidants. It is worthy be recommended in clinical treatment.

关 键 词：胆红素 超敏C反应蛋白 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]