急性胰腺炎患者血浆Apelin水平变化及临床意义  

Change of plasma Apelin level in patients with acute pancreatitis and its clinical significance

作　　者：邱秋[1] 李国均[2] 彭虹[1] 杨联云 

机构地区：[1]重庆市合川区人民医院消化内科,401520 [2]重庆市合川区人民医院血液内科,401520 [3]重庆市合川区人民医院检验科,401520

出　　处：《重庆医学》2018年第1期40-42,共3页Chongqing medicine

基　　金：重庆市卫生和计划生育委员会医学科研资助项目(2015XMSB000844)

摘　　要：目的探讨急性胰腺炎(AP)患者的血浆Apelin-13、Apelin-36水平变化情况及其临床意义。方法收集该院2015年7月至2016年6月50例AP患者作为AP组,分为轻型组(MAP组)和重型组(SAP组),另选择同期体检的健康志愿者30例作为对照组,比较各组入院时血浆Apelin-13、Apelin-36、C反应蛋白(CRP)水平和APACHEⅡ评分的差异,分析Apelin-13、Apelin-36与APACHEⅡ评分的相关性;比较入院第4天MAP组和SAP组的血浆Apelin-13、Apelin-36、CRP水平的差异。结果入院时AP组的血浆Apelin-13、Apelin-36、CRP水平及APACHEⅡ评分均显著高于对照组(P<0.05),SAP组的血浆Apelin-13、Apelin-36水平和APACHEⅡ评分高于MAP组(P<0.05),血浆Apelin-13、Apelin-36水平与APACHEⅡ评分呈显著正相关(P<0.05);入院第4天SAP组的血浆Apelin-13、Apelin-36和CRP水平高于MAP组(P<0.05)。结论 AP患者早期有血浆Apelin-13、Apelin-36水平改变,且与疾病严重程度密切相关,是早期识别SAP的有效指标。Objective To explore the change of plasma Apelin level in the patients with acute pancreatitis（AP） and its clini- cal significance. Methods Fifty cases of AP in the hospital from July 2015 to June 2016 were collected as the AP group and divided into the mild AP group（MAP） and severe AP group（SAP）. Other contemporaneous 30 healthy volunteers undergoing physical examination were selected as the control group. The differences in Apelin-13,Apelin-36 and C reactive protein（CRP） levels on admis- sion and were APACHE Ⅱ score were compared between the two groups. The correlation between Apelin-13 and Apelin-36 with APACHE ]I score was analyzed. The differences of plasma CRP, Apelin-13 and Apelin-36 levels on 4 d after admission were compared between the MAP group and SAP group. Results Plasma Apelin-36,Apelin-36 and CRP levels and APACHE Ⅱ score on admission in the AP group were significantly higher than that in the control group（P〈0.05）,plasma Apelin-13,Apelin-36 and CRP levels and APACHE Ⅱ score in the SAP group were significantly higher than those in the MAP group（P〈0.05） ,the plasma Ape- lin-13 and Apelin-36 levels were positively correlated with the APACHE Ⅱ score（P〈0.05）;the plasma Apelin-36, Apelin-36 and CRP levels on 4 d after admission in the SAP group were higher than those in the MAP group（P-0.05）. Conclusion Early stage of AP has the changes of plasma Apelin-13 and Apelin-36 levels,which are closely correlated with the severity of disease.

关 键 词：胰腺炎 危险性评估 APELIN-13 Apelin-36 

分 类 号：R576[医药卫生—消化系统]