肝硬化门脉高压性胃病患者血清胃蛋白酶原Ⅰ和Ⅱ水平  

A Study of Serum Pepsinogen Ⅰ and Ⅱ Level in Prediction of Patients with Liver Cirrhosis Portal Hypertensive Gastropathy

作　　者：刘立明[1] 周力[2] 李婷颖[3] 刘太阳[3] 余劲松[3] 杨杰[2] 

机构地区：[1]保定市第一中心医院内窥镜室,河北保定071000 [2]贵州医科大学附院消化内科,贵州贵阳550004 [3]贵州医科大学,贵州贵阳550004

出　　处：《贵州医科大学学报》2017年第12期1443-1446,共4页Journal of Guizhou Medical University

基　　金：贵州省科技厅科技计划项目[黔科合LG字(2012)009]

摘　　要：目的:探讨肝硬化门脉高压性胃病(PHG)患者血清中胃蛋白酶原Ⅰ与Ⅱ的水平变化。方法:46例肝硬化患者,经胃镜评价分为PHG组(n=17)及非PHG组(n=29),同期健康体检者20例作为对照组;3组受检者于就诊或体检时采集空腹静脉血,采用ELISA法检测血清胃蛋白酶原Ⅰ(PGⅠ)和PGⅡ含量,计算PGⅠ/PGⅡ比值(PGR)。结果:PHG组和对照组血清PGⅠ水平低于非PHG组,差异有统计学意义(P<0.05),而PHG组与对照组比较,差异无统计学意义(P>0.05);PHG组和非PHG组的PGⅡ水平高于对照组,差异有统计学意义(P<0.05),而PHG组和非PHG组比较,差异无统计学意义(P>0.05);3组PGR比较,PHG组<非PHG组<对照组,差异有统计学意义(P<0.05)。结论:肝硬化患者血清PGⅠ水平和PGR值降低可预示PHG的发生。Objective： To investigate the change of serum pepsinogen I and pepsinogen II level in patients with liver cirrhosis portal hypertensive gastropathy（ PHG）. Methods： 46 patients with liver cirrhosis were divided into PHG group（ n = 17） and non-PHG group（ n = 29）,and 20 healthy volunteers as control group. Fasting venous blood of three groups were collected while treatment or physical check,adopting ELISA assay to detect PG I and PG II content and calculating PG I/PG II ratio（ PGR）. Results： The level of serum PGI in the PHG group was lower than that of non-PHG group,differences were statistically significant（ P〈0. 05）; PHG group and control group comparison showed no statistically difference（ P〈0. 05）. PG II level of PHG group and non-PHG group were higher than that of control group,differences were statistically significant（ P〈0. 05）; the level of PGⅡ showed no difference between the PHG group and non-PHG group（ P〈0. 05）; PGR comparison of three groups showed that PHG group non-PHG group control group,differences were statistically significant（ P〈0. 05）. Conclusion： Lowered level of serum PGI may predict the development of PHG in liver cirrhosis.

关 键 词：肝硬化 高血压 门脉 胃镜检查 胃黏膜 胃蛋白酶原 

分 类 号：R575.21[医药卫生—消化系统] R446.112[医药卫生—内科学]