非糖尿病人群空腹血糖与脑梗死的队列研究  

Relationship between fasting blood glucose and cerebral infarction in non-diabetics

作　　者：王丰 王静[2] 黄喆[3] 陈朔华[3] 吴寿岭[3] 

机构地区：[1]北京大学第六医院北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100191 [2]北京大学医学信息学中心 [3]开滦总医院心血管内科

出　　处：《中华高血压杂志》2017年第11期1044-1049,共6页Chinese Journal of Hypertension

摘　　要：目的研究非糖尿病人群中空腹血糖水平对新发脑梗死的影响。方法选择2006-2010年符合纳入排除标准的开滦集团职工为随访对象,分析不同空腹血糖水平下脑梗死事件的发生情况。结果本研究纳入样本84 002例,年龄为30~70(51.1±13.0)岁,男性66 464例。随访时间为(47.8±3.2)个月。随访期间有887例观察对象发生脑梗死,累积发病率为1.06%。按性别分层后,男性空腹血糖<4.6、4.6~<5.6及≥5.6mmol/L组的累积发病率分别为1.42%、1.02%、1.41%;女性空腹血糖<4.6、4.6~<5.6及≥5.6mmol/L组的累积发病率分别为0.35%、0.53%、0.67%。应用Cox回归模型校正收缩压、舒张压、总胆固醇、吸烟和饮酒等指标后,在男性人群中,与4.6~5.6mmol/L组相比,空腹血糖≥5.6mmol/L组发生脑梗死事件的相对风险为1.29(95%CI 1.08~1.55)。女性人群中未发现此相关性。结论在非糖尿病人群中,空腹血糖水平≥5.6mmol/L增加男性脑梗死的发生风险。Objective To evaluate the relationship between fasting blood glucose on new onset cerebral infarction in non-diabetics. Methods Employees without diabetes of the Kailuan group company during 2006-2010 who met the inclusion and exclusion criteria were followed up, and the differences of cerebral infarction incidence between different fasting blood glucose groups were analyzed. Results The cohort consisted of 84 002 participants with mean age of （51.1±13.0 ） （30--70） years, of which there were 66 464 males. The mean duration of follow-up was （47.8±3.2） months. A total of 887 patients had cerebral infarctions. The cumulative incidence was 1.06%. After being stratified by gender, the cumulative incidences of patients with an fasting blood glucose 〈4.6, 4.6-- 〈5.6, and ≥5.6 mmol/L were 1.42 G, 1.02 %, and 1.41% in males and 0.350%, 0.53 %, and 0.67 % in females, respectively. Compared with the 4.6-〈5.6 mmol/L group, the Cox proportional hazard model showed a hazard ratio for cerebral infarction in males was 1.29 （95% CI 1.08- 1.55） in the fasting blood glucose ≥5.6 mmol/L group when adjusted for systolic blood pressure, diastolic blood pressure, total cholesterol, smoking cigarettes, and consuming alcohol. No such correlation was found in females. Conclusion The incidence of cerebral infarction can be high in non-diabetics males whose fasting blood glucose ≥5.6 mmol/L.

关 键 词：新发脑梗死 糖尿病 空腹血糖 

分 类 号：R743.3[医药卫生—神经病学与精神病学]