年龄因素对成年人角膜厚度的影响  

Age-Related Changes in Corneal Thickness in Adults

作　　者：冯雪莹 王青[2] 石中云 尹晓妮[2] 高琳[2] 李慧[2] 周姝 

机构地区：[1]青岛大学,266071 [2]青岛大学附属医院眼科,266003

出　　处：《中华眼视光学与视觉科学杂志》2017年第12期727-731,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：国家自然科学基金（81300790）

摘　　要：目的：探讨不同年龄段成年人角膜厚度的差异。方法：横断面研究。选择2015 年8-12 月就诊于青岛大学附属医院眼科的近视及白内障患者300 例（300 眼）。按年龄分为3 组：青年组96 例，平均年龄（26.4±5.5）岁；中年组86 例，平均年龄（62.1±6.8）岁；老年组118 例，平均年龄（79.2±5.6）岁。应用Galilei眼前房分析系统测量各组的角膜厚度。对各组中央角膜厚度（CCT）、旁中央角膜厚度（PaCT）、周边角膜厚度（PeCT）及角膜最薄点厚度（TCT）等指标进行比较分析。采用单因素方差分析、Kruskal-Wallis H秩和检验、Pearson相关分析及Spearman相关分析对数据进行分析。结果：3 组间CCT、PaCT差异均无统计学意义。PeCT总体差异有统计学意义（H =39.12，P 〈 0.001），且青年组PeCT均比中年组和老年组PeCT厚（P 〈 0.05）。3组间TCT总体差异有统计学意义（H=31.63，P 〈 0.001），且青年组TCT比中年组TCT厚（P =0.002），中年组TCT比老年组TCT厚（P =0.002）。在各组内，中年组PeCT与年龄呈负相关（r =-0.288，P =0.007），青年组、老年组的CCT、PaCT、PeCT、TCT与年龄均无相关性。对于总体，CCT、PaCT与年龄无相关性，而PeCT、TCT与年龄均呈负相关（r =-0.369、-0.343，P 〈 0.001）。结论：成年人的CCT、PaCT不随年龄的变化而改变，PeCT、TCT随年龄增长有变薄的趋势。Objective： To investigate adult age-related changes in corneal thickness. Methods： In this cross-sectional study, one eye in each of 300 myopia and cataract outpatients at the Affiliated Hospital of Qingdao University from August to December, 2015 was studied. The patients were divided into three groups： Young （21 to 45 years old, [mean ± standard deviation] 26.4 ± 5.5 years, 96 eyes）; Middle-aged （46 to 70 years old, 62.1±6.8 years, 86 eyes）; and Elder （71 to 92 years old, 79.2 ± 5.6 years, 118 eyes）. The Galilei Dual Scheimpflug Analyzer was used to measure corneal pachymetry. Central corneal thickness （CCT） and paracentral corneal thickness （PaCT） were evaluated by analysis of variance, and peripheral corneal thickness （PeCT） and thinnest corneal thickness （TCT） were analyzed by Kruskal-Wallis H rank-sum test. The relationship between the variables and age were analyzed by Pearson correlation analysis and Spearman correlation analysis. Results： There were no significant differences among the three groups in CCT and PaCT. Among the three groups there were significant differences in PeCT （H=39.12, P〈0.001）.The PeCT of the Young Group was thicker than both the Middle-aged Group （P =0.017） and the Elder Group （P 〈0.001）, but the difference in thickness between the Middle-aged and Elder Groups was not significant （P=0.193）. For TCT, there were significant differences among the three groups （H=31.63, P〈0.001）. The TCT of the Young Group was thicker than both the Middle-aged Group （P =0.002） and the Elder Group （P〈0.001）, and the TCT of the Middle-aged Group was thicker than the Elder Group （P =0.002）.PeCT was weakly correlated with age in the Middle-aged Group （r=-0.288, P =0.007）. Other variables were not correlated with age in any of the groups. In general, CCT and PaCT were not correlated with age. In contrast, PeCT and TCT were negatively correlated with age （r=-0.369, -0.343, P 〈0.001）. Conclusions：As people age, PeCT an

关 键 词：年龄因素 中央角膜厚度 旁中央角膜厚度 周边角膜厚度 角膜最薄点厚度 

分 类 号：R772.2[医药卫生—眼科]