帕金森病伴认知障碍及Alzheimer's病患者听觉事件相关诱发电位的特点分析  

Comparative study of audition event-related potentials in patient with Parkinson's disease with cognitive impairment and Alzheimer's disease

作　　者：赵洁皓 黄智恒 何雪桃 聂坤 张玉虎 王丽娟 

机构地区：[1]广东省人民医院(广东省医学科学院)神经内科,广州510018

出　　处：《临床神经病学杂志》2017年第6期401-404,共4页Journal of Clinical Neurology

基　　金：国家自然科学基金(30801219;30870863);广东省科技计划项目(2011B080701087)

摘　　要：目的比较帕金森病(PD)伴认知功能障碍,轻度认知功能障碍(MCI)及Alzheimer's病(AD)患者听觉事件相关诱发电位(ERP)的特点。方法共计261名受试者,分为帕金森病伴痴呆(PDD)组21例,帕金森病伴轻度认知功能障碍(PDMCI)组48例,及帕金森病认知正常(PDCN)组54例,AD组60例,MCI组35例,和正常对照组(NC组)43名,均进行神经系统及神经心理检查,功能评定,神经影像检查并记录ERPs,包括感觉(N100、P200)及认知(N200、P300)ERPs。分析ERPs在各组的变化及特点。结果与NC组相比,MCI组,PDCN组P3潜伏期均明显延长(均P<0.05)。与MCI组相比,PDMCI组P3潜伏期明显延长(P<0.05)。与NC组相比,PDMCI组N2潜伏期明显延长(P<0.05);MCI组N2潜伏期差异无统计学意义(P>0.05)。结论 P3潜伏期是PDMCI、MCI、AD认知障碍敏感的神经电生理指标,尤其在PD患者。与AD、MCI的ERPs相比较,PD认知障碍患者较早出现N2、P3潜伏期的延长,反映了AD和PDD认知障碍发展过程的不同。Objective To compare auditory event-related evoked potentials（ ERPs） features for the patients with mild cognitive impairment（ MCI）,Alzheimer＇s disease（ AD） and Parkinson＇s disease（ PD） with cognitive function disorders. Methods Two hundred and sixty-one subjects were divided into： Parkinson＇s dementia（ PDD）group（ n = 21）,PD with mild cognitive impairment（ PDMCI） group（ n = 48）,PD without cognitive impairment（ PDCN） group（ n = 54）,AD group（ n = 60）,MCI group（ n = 35） and the normal control（ NC） group（ n = 43）.They all underwent neurological and neuropsychological examination,functional assessment,neurological imaging and recorded event-related evoked potentials,including sensory（ N100,P200） and cognitive（ N200,P300） events evoked potentials. The changes and characteristics of ERPs in each group were analyzed. Results Compared with the NC group,P3 latency in MCI and PDCN group was significantly longer（ all P 0. 05）. Compared with MCI group,P3 latency extended was more significant（ P 0. 05）. Compared with NC group,N2 latency was significantly longer in PDMCI group（ P 0. 05）; but not in the MCI group（ P 0. 05）. Conclusions P3 can serve as sensitive nerve electrophysiological index assisted diagnosis in PDMCI,MCI and AD,especially in PD patients. The various characteristics of ERPs between PD with cognitive impairment and AD and MCI,including prolonger of N2 latency and P3 latency appears at early stage of the PD with cognitive impairment,reflect the differenct development process of cognitive disorders between the AD and PDD.

关 键 词：事件相关诱发电位 轻度认知功能障碍 认知 帕金森病 Alzheimer's病 

分 类 号：R742.5[医药卫生—神经病学与精神病学]